SHEET /best/deadliest · LEADERBOARD
Deadliest
from sourcecomputed
Ranked by the lowest reported oral LD50, preferring the rat and then the mouse so the numbers compare like with like. Every row names its route and species. A molecule measured only by injection is not listed here, because an injected dose is not a swallowed one. Animal data shown as neutral science: an estimate, never a threshold to act on.
#MoleculeLD50RouteRelative
01ColchicineC22H25NO65.89 mg/kgoral · mouse02IndometacinC19H16ClNO412 mg/kgoral · rat03DigoxinC41H64O1417.78 mg/kgoral · mouse04FentanylC22H28N2O18 mg/kgoral · rat05NorepinephrineC8H11NO320 mg/kgoral · mouse06AmphetamineC9H13N22 mg/kgoral · mouse07DextroamphetamineC9H13N38 mg/kgoral · rat08LoperamideC29H33ClN2O240 mg/kgoral · dog09MethotrexateC20H22N8O543 mg/kgoral · rat10Sodium fluorideFNa44.3 mg/kgoral · mouse11CapsaicinC18H27NO347.2 mg/kgoral · rat12MethanethiolCH4S61 mg/kgoral · mouse13TelluriumTe83 mg/kgoral · rat14MeloxicamC14H13N3O4S284 mg/kgoral · rat15Sodium nitriteNNaO285 mg/kgoral · rat16MethadoneC21H27NO86 mg/kgoral · rat17SilverAg100 mg/kgoral · mouse18FormaldehydeCH2O100 mg/kgoral · rat19Allyl isothiocyanateC4H5NS112 mg/kgoral · rat20VerapamilC27H38N2O4114 mg/kgoral · rat21FluorouracilC4H3FN2O2115 mg/kgoral · mouse22PentobarbitalC11H18N2O3118 mg/kgoral · rat23AcrylamideC3H5NO124 mg/kgoral · rat24SecobarbitalC12H18N2O3125 mg/kgoral · rat25ClonidineC9H9Cl2N3126 mg/kgoral · rat26FurfuralC5H4O2127 mg/kgoral · rat27HaloperidolC21H23ClFNO2128 mg/kgoral · rat28TacrolimusC44H69NO12134 mg/kgoral · rat29BuspironeC21H31N5O2136 mg/kgoral · rat30AmitriptylineC20H23N140 mg/kgoral · mouse31ChlorpromazineC17H19ClN2S142 mg/kgoral · rat32DoxepinC19H21NO147 mg/kgoral · rat33Perfluorooctanesulfonic acidC8HF17O3S154 mg/kgoral · rat34CyclophosphamideC7H15Cl2N2O2P160 mg/kgoral · rat35QuercetinC15H10O7161 mg/kgoral · rat36PethidineC15H21NO2162 mg/kgoral · rat37NicotineC10H14N2188 mg/kgoral · rat38MethylphenidateC14H19NO2190 mg/kgoral · mouse39CaffeineC8H10N4O2192 mg/kgoral · rat40AspirinC9H8O4200 mg/kgoral · rat41DextromethorphanC18H25NO201 mg/kgoral · mouse42CadmiumCd225 mg/kgoral · rat43TramadolC16H25NO2228 mg/kgoral · rat44ImipramineC19H24N2250 mg/kgoral · rat45AmobarbitalC11H18N2O3250 mg/kgoral · rat46ClozapineC18H19ClN4251 mg/kgoral · rat47Potassium hydroxideHKO273 mg/kgoral · rat48CoumarinC9H6O2293 mg/kgoral · rat49TapentadolC14H23NO300 mg/kgoral · mouse50TheobromineC7H8N4O2300 mg/kgoral · dog51Copper(II) sulfateCuO4S300 mg/kgoral · rat52ApomorphineC17H17NO2300 mg/kgoral · mouse53LidocaineC14H22N2O317 mg/kgoral · rat54PhenolC6H6O317 mg/kgoral · rat55Iron(II) sulfateFeO4S319 mg/kgoral · rat56TheophyllineC7H8N4O2332 mg/kgoral · mouse57MorphineC17H19NO3335 mg/kgoral · rat58AmmoniaH3N350 mg/kgoral · rat59HydrocodoneC18H21NO3375 mg/kgoral · rat60Potassium chlorideClK383 mg/kgoral · mouse61NortriptylineC19H21N387 mg/kgoral · mouse62FlunitrazepamC16H12FN3O3415 mg/kgoral · rat63CyclobenzaprineC20H21N425 mg/kgoral · rat64CodeineC18H21NO3427 mg/kgoral · rat65Chloral hydrateC2H3Cl3O2479 mg/kgoral · rat66NaphthaleneC10H8490 mg/kgoral · rat67DiphenhydramineC17H21NO500 mg/kgoral · rat68DiclofenacC14H11Cl2NO2500 mg/kgoral · dog69ParoxetineC19H20FNO3500 mg/kgoral · mouse70DisulfiramC10H20N2S4500 mg/kgoral · rat71TrimethylamineC3H9N500 mg/kgoral · rat72GuaiacolC7H8O2520 mg/kgoral · rat73ChlordiazepoxideC16H14ClN3O537 mg/kgoral · rat74DoxorubicinC27H29NO11570 mg/kgoral · mouse75PromethazineC17H20N2S580 mg/kgoral · rabbit76BupropionC13H18ClNO600 mg/kgoral · rat77EphedrineC10H15NO600 mg/kgoral · rat78PermethrinC21H20Cl2O3600 mg/kgoral · rat79NitrofurantoinC8H6N4O5604 mg/kgoral · rat80Tert-ButylhydroquinoneC10H14O2615 mg/kgoral · rat81ZincZn630 mg/kgoral · rat82IbuprofenC13H18O2636 mg/kgoral · rat83LevofloxacinC18H20FN3O4640 mg/kgoral · rat84PhenobarbitalC12H12N2O3660 mg/kgoral · rat85AcetaldehydeC2H4O661 mg/kgoral · rat86MidodrineC12H18N2O4675 mg/kgoral · mouse87EthanethiolC2H6S682 mg/kgoral · rat88TrazodoneC19H22ClN5O690 mg/kgoral · rat89ZolpidemC19H21N3O695 mg/kgoral · rat90Formic acidCH2O2700 mg/kgoral · mouse91KetoconazoleC26H28Cl2N4O4702 mg/kgoral · mouse92DiazepamC16H13ClN2O710 mg/kgoral · rat93MetoclopramideC14H22ClN3O2750 mg/kgoral · rat94Potassium permanganateKMnO4750 mg/kgoral · rat95ArsenicAs763 mg/kgoral · rat96MeprobamateC9H18N2O4794 mg/kgoral · rat97AmantadineC10H17N800 mg/kgoral · rat98SirolimusC51H79NO13800 mg/kgoral · rat99Magnesium oxideMgO810 mg/kgoral · mouse100MidazolamC18H13ClFN3825 mg/kgoral · rat101HydroxyzineC21H27ClN2O2840 mg/kgoral · rat102RopiniroleC16H24N2O862 mg/kgoral · rat103Methyl salicylateC8H8O3887 mg/kgoral · rat104Butylated hydroxytolueneC15H24O890 mg/kgoral · rat105Salicylic acidC7H6O3891 mg/kgoral · rat106ThymolC10H14O980 mg/kgoral · rat107MetforminC4H11N51,000 mg/kgoral · rat108NifedipineC17H18N2O61,022 mg/kgoral · rat109ValproateC8H16O21,098 mg/kgoral · mouse110BisoprololC18H31NO41,112 mg/kgoral · rat111MethylglyoxalC3H4O21,165 mg/kgoral · rat112AlprazolamC17H13ClN41,220 mg/kgoral · rat113NaproxenC14H14O31,234 mg/kgoral · mouse114Sodium nitrateNNaO31,267 mg/kgoral · rat115ClarithromycinC38H69NO131,270 mg/kgoral · rat116Sodium lauryl sulfateC12H25NaO4S1,288 mg/kgoral · rat117BenzaldehydeC7H6O1,300 mg/kgoral · rat118Isoamyl alcoholC5H12O1,300 mg/kgoral · rat119CamphorC10H16O1,310 mg/kgoral · mouse120Raspberry ketoneC10H12O21,320 mg/kgoral · rat121Caprylic acidC8H16O21,410 mg/kgoral · rat122MaltolC6H6O31,410 mg/kgoral · guinea pig123NaltrexoneC20H23NO41,450 mg/kgoral · rat124CiclosporinC62H111N11O121,489 mg/kgoral · rat125ChloramphenicolC11H12Cl2N2O51,500 mg/kgoral · mouse126AlbendazoleC12H15N3O2S1,500 mg/kgoral · mouse127Phosphoric acidH3O4P1,530 mg/kgoral · rat128GlyphosateC3H8NO5P1,568 mg/kgoral · mouse129VanillinC8H8O31,580 mg/kgoral · rat130DiacetylC4H6O21,580 mg/kgoral · rat131DichloromethaneCH2Cl21,600 mg/kgoral · rat132FuraneolC6H8O31,608 mg/kgoral · mouse133PhenytoinC15H12N2O21,635 mg/kgoral · rat134CarvoneC10H14O1,640 mg/kgoral · rat135Ammonium chlorideClH4N1,650 mg/kgoral · rat136Benzyl benzoateC14H12O21,700 mg/kgoral · rat137L-DOPAC9H11NO41,780 mg/kgoral · rat138QuinineC20H24N2O21,800 mg/kgoral · guinea pig139ProchlorperazineC20H24ClN3S1,800 mg/kgoral · rat140TemazepamC16H13ClN2O21,833 mg/kgoral · rat141CysteineC3H7NO2S1,890 mg/kgoral · rat142DEETC12H17NO1,892 mg/kgoral · rat143BenzophenoneC13H10O1,900 mg/kgoral · rat144EugenolC10H12O21,930 mg/kgoral · rat145Benzoic acidC7H6O21,940 mg/kgoral · mouse146AcetaminophenC8H9NO21,944 mg/kgoral · rat147SafroleC10H10O21,950 mg/kgoral · rat148Glycolic acidC2H4O31,950 mg/kgoral · rat149TretinoinC20H28O21,960 mg/kgoral · rat150Brilliant blue FCFC37H34N2Na2O9S32,000 mg/kgoral · rat151CandesartanC24H20N6O32,000 mg/kgoral · rat152AcetophenoneC8H8O2,081 mg/kgoral · rat153Sulfuric acidH2O4S2,140 mg/kgoral · rat154Bisphenol AC15H16O22,230 mg/kgoral · rabbit155Phenylacetic acidC8H8O22,250 mg/kgoral · rat156Succinic acidC4H6O42,260 mg/kgoral · rat157EucalyptolC10H18O2,480 mg/kgoral · rat158RetinolC20H30O2,570 mg/kgoral · mouse159Propionic acidC3H6O22,600 mg/kgoral · rat160DocusateC20H37NaO7S2,640 mg/kgoral · mouse161BoraxB4Na2O72,660 mg/kgoral · rat162PiperonalC8H6O32,700 mg/kgoral · rat163LinaloolC10H18O2,790 mg/kgoral · rat164Sodium carbonateCNa2O32,800 mg/kgoral · rat165Methyl anthranilateC8H9NO22,910 mg/kgoral · rat166Zinc sulfateO4SZn2,949 mg/kgoral · rat167Sodium chlorideClNa3,000 mg/kgoral · rat168Citric acidC6H8O73,000 mg/kgoral · rat169AcetylcysteineC5H9NO3S3,000 mg/kgoral · rat170Malic acidC4H6O53,000 mg/kgoral · rabbit171AtenololC14H22N2O33,000 mg/kgoral · rat172BisacodylC22H19NO43,000 mg/kgoral · rat173MyristicinC11H12O33,000 mg/kgoral · mouse174Potassium nitrateKNO33,015 mg/kgoral · rat175BenzocaineC9H11NO23,040 mg/kgoral · rat176SiliconSi3,160 mg/kgoral · rat177MelamineC3H6N63,161 mg/kgoral · rat178LorazepamC15H10Cl2N2O23,178 mg/kgoral · mouse179MelatoninC13H16N2O23,200 mg/kgoral · rat180MentholC10H20O3,300 mg/kgoral · rat181Dimethyl sulfideC2H6S3,300 mg/kgoral · rat182BenzeneC6H63,306 mg/kgoral · rat183CinnamaldehydeC9H8O3,400 mg/kgoral · rat184Choline chlorideC5H14ClNO3,400 mg/kgoral · rat185Sodium benzoateC7H5NaO23,450 mg/kgoral · rat186Methylene blueC16H18ClN3S3,500 mg/kgoral · mouse187NicotinamideC6H6N2O3,500 mg/kgoral · rat188Sodium acetateC2H3NaO23,500 mg/kgoral · rat189Acetic acidC2H4O23,530 mg/kgoral · rat190MethoxyfluraneC3H4Cl2F2O3,600 mg/kgoral · rat191GeraniolC10H18O3,600 mg/kgoral · rat192Ethylenediaminetetraacetic acidC10H16N2O83,700 mg/kgoral · rat193α-PineneC10H163,700 mg/kgoral · rat194TriclosanC12H7Cl3O23,700 mg/kgoral · rat195ThiamineC12H17N4OS+3,710 mg/kgoral · rat196Lactic acidC3H6O33,730 mg/kgoral · rat197MiconazoleC18H14Cl4N2O3,800 mg/kgoral · mouse198OmeprazoleC17H19N3O3S4,000 mg/kgoral · rat199Sodium bicarbonateCHNaO34,220 mg/kgoral · rat200β-IononeC13H20O4,590 mg/kgoral · rat201Ethylene glycolC2H6O24,700 mg/kgoral · rat202Isopropyl alcoholC3H8O4,797 mg/kgoral · dog203Ethyl acetateC4H8O24,900 mg/kgoral · rabbit204Potassium sorbateC6H7KO24,920 mg/kgoral · rat205LimoneneC10H165,000 mg/kgoral · rat206Vitamin CC6H8O65,000 mg/kgoral · rat207LoratadineC22H23ClN2O25,000 mg/kgoral · rat208TolueneC7H85,000 mg/kgoral · rat209Aluminium oxideAl2O35,000 mg/kgoral · rat210VancomycinC66H75Cl2N9O245,000 mg/kgoral · mouse211HexaneC6H145,000 mg/kgoral · mouse212TriazolamC17H12Cl2N45,000 mg/kgoral · rat213Azelaic acidC9H16O45,000 mg/kgoral · rat214OxazepamC15H11ClN2O25,000 mg/kgoral · rat215SqualeneC30H505,000 mg/kgoral · mouse216Aluminium hydroxideAlH3O35,000 mg/kgoral · rat217Calcium gluconateC12H22CaO145,000 mg/kgoral · rat218Gallic acidC7H6O55,000 mg/kgoral · rabbit219MyrceneC10H165,000 mg/kgoral · rat220ChlorhexidineC22H30Cl2N105,000 mg/kgoral · rat221LevonorgestrelC21H28O25,010 mg/kgoral · rat222GlycerolC3H8O35,570 mg/kgoral · rat223EthanolC2H6O5,628 mg/kgoral · rat224MethanolCH4O5,628 mg/kgoral · rat225AcetoneC3H6O5,800 mg/kgoral · rat226NorethisteroneC20H26O26,000 mg/kgoral · mouse2274-Aminobenzoic acidC7H7NO26,000 mg/kgoral · rat228CobaltCo6,171 mg/kgoral · rat229SulfamethoxazoleC10H11N3O3S6,370 mg/kgoral · rat230Calcium carbonateCCaO36,450 mg/kgoral · rat231SeleniumSe6,700 mg/kgoral · rat232AntimonySb7,000 mg/kgoral · rat233TaurineC2H7NO3S7,000 mg/kgoral · rat234Nicotinic acidC6H5NO27,000 mg/kgoral · rat235Isoamyl acetateC7H14O27,422 mg/kgoral · rabbit236GlutamineC5H10N2O37,500 mg/kgoral · rat237Benzoyl peroxideC14H10O47,710 mg/kgoral · rat238GabapentinC9H17NO28,000 mg/kgoral · rat239UreaCH4N2O8,471 mg/kgoral · rat240Butyric acidC4H8O28,790 mg/kgoral · rat241Sodium hypochloriteClNaO8,910 mg/kgoral · rat242ManganeseMn9,000 mg/kgoral · rat243ErythromycinC37H67NO139,272 mg/kgoral · rat244CarbonC10,000 mg/kgoral · rat245BiotinC10H16N2O3S10,000 mg/kgoral · mouse246AciclovirC8H11N5O310,000 mg/kgoral · mouse247RiboflavinC17H20N4O610,000 mg/kgoral · rat248Myristic acidC14H28O210,000 mg/kgoral · rat249Sorbic acidC6H8O210,500 mg/kgoral · rat250Lauric acidC12H24O212,000 mg/kgoral · rat251MannitolC6H14O613,500 mg/kgoral · rat252IodineI214,000 mg/kgoral · rat253SaccharinC7H5NO3S14,200 mg/kgoral · rat254ClonazepamC15H10ClN3O315,000 mg/kgoral · rat255DexpanthenolC9H19NO415,000 mg/kgoral · mouse256SorbitolC6H14O615,900 mg/kgoral · rat257Disodium phosphateHNa2O4P17,000 mg/kgoral · rat258Erucic acidC22H42O219,431.7 mg/kgoral · rat259Propylene glycolC3H8O222,000 mg/kgoral · rat260Silicon dioxideO2Si22,500 mg/kgoral · rat261PhylloquinoneC31H46O225,000 mg/kgoral · mouse262GlucoseC6H12O625,800 mg/kgoral · rat263PiracetamC6H10N2O226,000 mg/kgoral · mouse264SucroseC12H22O1129,700 mg/kgoral · rat265Oleic acidC18H34O274,000 mg/kgoral · rat← All leaderboards · values carry source citations; the ranking regenerates on every ETL run from source