SHEET /m/mannitol · PubChem CID 6251 · CAS 69-65-8 · REV 2026.07
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Mannitol from source
C6H14O6 · 182.17 g/mol
D-mannitol · Mannite · Osmitrol · Manna sugar
chemical compound
CategorySweetener
Chemical familyAlcohols
Fig. 1 · 2D structure RDKit
C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O
Where you'll find it
Not yet mapped to everyday foods or products.
The dose makes the poison inferred
A reported rat oral LD50 for Mannitol is 13,500 mg/kg, the dose lethal to half the animals tested. Scaled by body mass alone:
945.0 g
a median lethal dose scaled to 154 lb (945,000 mg)
“The dose makes the poison” is a cross-species estimate shown as neutral science, not a threshold anyone should act on. Real toxicity depends on the person, not body mass alone.
Toxicity & hazards
Toxicity · LD50
13,500 mg/kg · very low toxicity · LD50 rat oral from source
The dose lens above scales this to a body weight.
4 more reported values
- 22,000 mg/kgLD50 · oral · mouse
- 7,470 mg/kgLD50 · iv · mouse
- 9,690 mg/kgLD50 · iv · rat
- 14,000 mg/kgLD50 · other · mouse
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