moleculefinder

Bupropion

C13H18ClNO239.74 g/mol Calculated

Also called amfebutamone.

An antidepressant, sold as Wellbutrin and Zyban, also used to help people stop smoking. Chemically it is a substituted cathinone rather than an SSRI.

Sources and notes
  • The introductionfrom sourceMoleculeFinder curated
  • Other namesfrom sourceWikidataIts English label and aliases on Wikidata.
  • Formula and weightcomputedPubChem
  • 2D drawingcomputedPubChem structure, drawn by RDKit
  • 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.

Where you encounter it

Dispensed on prescription, not sold on a shelf. Bupropion on the product labels we hold.

Medicines

Wellbutrin SRAdded by the makerActive ingredient

Every product and list we hold

Sources and notes
  • The product labels and their strengthsfrom sourceDailyMed (FDA label)Each label lists the molecule as an ingredient, and an active ingredient at the strength shown.
  • How it gets therefrom sourceMoleculeFinder curatedEach mark is set by hand on our lists, never inferred; a label's ingredient is added by the maker. A row with no mark data says Not marked.
  • The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.

Explore its structure

Choose a part to light it up.

A C=O with a carbon on each side. Its oxygen accepts hydrogen bonds but has no hydrogen to give, and it resists oxidation better than an aldehyde.

From: standard chemistry.

Sources and notes
  • The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
  • The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.

Compare a related molecule

Bupropion

Sertraline

Sertraline is an SSRI that acts on serotonin, while bupropion acts on dopamine and norepinephrine and leaves serotonin essentially alone.

Bupropion vs Sertraline, side by side
Sources and notes
  • The sentencefrom sourceMoleculeFinder comparison notesThe pair's answer line.
  • The two drawingscomputedPubChem structures, drawn by RDKitThe two drawings side by side.

Properties and sources

Calculated by PubChem

Molecular formula
C13H18ClNO
Molecular weight
239.74 g/mol
XLogP3octanol/water, log units
3.2
Polar surface areatopological
29.1 Ų
H-bond donors
1
H-bond acceptors
2
Rotatable bonds
4
Complexity
247

Measured LD50, HSDB via PubChem

600 mg/kg pure bupropion, rat, oral

An LD50 is an animal study measurement, not a dose for a person.

Reported Hazard label (GHS), HSDB via PubChem

Warning Irritant pictogram (GHS07); hazard statements H302

Reported Licence

The US Food and Drug Administration licenses Bupropion for human use (NDA 020358, authorized October 4, 1996), as Wellbutrin SR. Drugs@FDA

Groups it belongs to

Category
Prescription medicine
Family
Antidepressants
Chemical groups
Amines, Aromatics, Ketones, Halogenated
Elements
Chlorine, Nitrogen
Hazard classes
Irritant, GHS Warning
SMILESCC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C

PubChem CID 444 · Wikidata Q834280 · InChIKey SNPPWIUOZRMYNY-UHFFFAOYSA-N · Data refreshed

How MoleculeFinder sources and labels its data

Questions
What is Bupropion?
An antidepressant, sold as Wellbutrin and Zyban, also used to help people stop smoking. Chemically it is a substituted cathinone rather than an SSRI.
How toxic is Bupropion?
The reported LD50 of Bupropion is 600 mg/kg (rat, oral). An LD50 is an animal study measurement, not a dose for a person. Its GHS hazard label carries the signal word Warning and the hazard pictogram Irritant. from sourcefrom source
What kind of molecule is Bupropion?
Bupropion has the formula C13H18ClNO and a molecular weight of 239.74 g/mol. MoleculeFinder files it under antidepressants, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
What else is Bupropion called?
Bupropion is also called amfebutamone. from source
Who licenses Bupropion as a medicine?
The US Food and Drug Administration licenses Bupropion for human use (NDA 020358, authorized October 4, 1996), as Wellbutrin SR. from source
Sources and notes
  • Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
  • LD50from sourceHSDB via PubChemOther values the sources report: mouse, oral, 575 mg/kg; rat, another route, 210 mg/kg; mouse, another route, 230 mg/kg. The page shows the one LD50 the site uses everywhere.
  • Hazard labelfrom sourceHSDB via PubChemThe label combines these classifications.
  • Licencefrom sourceDrugs@FDARead 2026-10-21.
  • Data refreshedfrom sourceMoleculeFinder2026-11-09

Keep exploring

Compared side by side with bupropionSertralineC17H17Cl2N
Sources and notes
  • Compared side by sidefrom sourceMoleculeFinder comparison notesA molecule we compare it with on its own page.
  • The drawingscomputedPubChem structures, drawn by RDKit