moleculefinder

Sertraline

C17H17Cl2N306.2 g/mol Calculated

Also called Altruline and Besitran.

The SSRI antidepressant sold as Zoloft, used for depression, anxiety and OCD. It blocks the pump that pulls serotonin back into nerve cells, so more stays in the gap between them.

Sources and notes
  • The introductionfrom sourceMoleculeFinder curated
  • Other namesfrom sourcePubChem / Wikidata
  • Formula and weightcomputedPubChem
  • 2D drawingcomputedPubChem structure, drawn by RDKit
  • 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.

Where you encounter it

Dispensed on prescription, not sold on a shelf. Sertraline on the product labels we hold.

Medicines

ZoloftAdded by the makerActive ingredient

Every product and list we hold

Sources and notes
  • The product labels and their strengthsfrom sourceDailyMed (FDA label)Each label lists the molecule as an ingredient, and an active ingredient at the strength shown.
  • How it gets therefrom sourceMoleculeFinder curatedEach mark is set by hand on our lists, never inferred; a label's ingredient is added by the maker. A row with no mark data says Not marked.
  • The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.

Explore its structure

Choose a part to light it up.

A nitrogen carrying one or two hydrogens. Its spare pair of electrons can pick up a hydrogen ion, so an amine is a base.

From: standard chemistry.

Sources and notes
  • The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
  • The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.

Compare a related molecule

Sertraline

Fluoxetine

Sertraline and fluoxetine are both SSRIs, but fluoxetine and its active metabolite linger for a week or more while sertraline clears in a day or two.

Sertraline vs Fluoxetine, side by side

Also compared

Sources and notes
  • The sentencefrom sourceMoleculeFinder comparison notesThe pair's answer line.
  • The two drawingscomputedPubChem structures, drawn by RDKitThe two drawings side by side.

Properties and sources

Calculated by PubChem

Molecular formula
C17H17Cl2N
Molecular weight
306.2 g/mol
XLogP3octanol/water, log units
4.8
Polar surface areatopological
12 Ų
H-bond donors
1
H-bond acceptors
1
Rotatable bonds
2
Complexity
322

Reported Hazard label (GHS), ECHA via PubChem

Warning Irritant pictogram (GHS07) and Environmental pictogram (GHS09); hazard statements H302, H411

Reported Licence

The US Food and Drug Administration licenses Sertraline for human use (NDA 019839, authorized December 30, 1991), as Zoloft. Drugs@FDA

Groups it belongs to

Category
Prescription medicine
Family
SSRIs
Chemical groups
Amines, Aromatics, Halogenated
Elements
Chlorine, Nitrogen
Hazard classes
Irritant, Environmental hazard, GHS Warning
SMILESCN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl

PubChem CID 68617 · Wikidata Q407617 · InChIKey VGKDLMBJGBXTGI-SJCJKPOMSA-N · Data refreshed

How MoleculeFinder sources and labels its data

Questions
What is Sertraline?
The SSRI antidepressant sold as Zoloft, used for depression, anxiety and OCD. It blocks the pump that pulls serotonin back into nerve cells, so more stays in the gap between them.
How toxic is Sertraline?
Its GHS hazard label carries the signal word Warning and the hazard pictograms Irritant and Environmental. from source
What kind of molecule is Sertraline?
Sertraline has the formula C17H17Cl2N and a molecular weight of 306.2 g/mol. MoleculeFinder files it under SSRIs, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
Who licenses Sertraline as a medicine?
The US Food and Drug Administration licenses Sertraline for human use (NDA 019839, authorized December 30, 1991), as Zoloft. from source
Sources and notes
  • Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
  • Hazard labelfrom sourceECHA via PubChemThe label combines these classifications.
  • ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
  • Licencefrom sourceDrugs@FDARead 2026-10-21.
  • Data refreshedfrom sourceMoleculeFinder2026-11-09

Keep exploring

Compared side by side with sertralineFluoxetineC17H18F3NOCompared side by side with sertralineEscitalopramC20H21FN2OCompared side by side with sertralineBupropionC13H18ClNO
Sources and notes
  • Compared side by sidefrom sourceMoleculeFinder comparison notesA molecule we compare it with on its own page.
  • The drawingscomputedPubChem structures, drawn by RDKit