Clozapine
Also called Clorazil, Fazaclo, Fazaclo ODT and Leponex.
An atypical antipsychotic reserved for schizophrenia that has not responded to anything else, because it demands regular blood monitoring.
Sources and notes
- The introductionfrom sourceMoleculeFinder curated
- Other namesfrom sourcePubChem / Wikidata
- Formula and weightcomputedPubChem
- 2D drawingcomputedPubChem structure, drawn by RDKit
- 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.
Where you encounter it
Dispensed on prescription, not sold on a shelf. Clozapine on the product labels we hold.
Medicines
Every product and list we hold
Sources and notes
- The product labels and their strengthsfrom sourceDailyMed (FDA label)Each label lists the molecule as an ingredient, and an active ingredient at the strength shown.
- How it gets therefrom sourceMoleculeFinder curatedEach mark is set by hand on our lists, never inferred; a label's ingredient is added by the maker. A row with no mark data says Not marked.
- The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.
Explore its structure
Choose a part to light it up.
A nitrogen bonded to three carbons, with no hydrogen of its own. Its spare pair of electrons can still pick up a hydrogen ion, so a tertiary amine is a base.
From: standard chemistry.
Fluorine, chlorine, bromine or iodine bonded to carbon. Each pulls electrons toward itself, and each is larger than the hydrogen the carbon would otherwise carry.
From: standard chemistry.
Rings joined where they share atoms, or a single ring standing alone. Atoms in a ring are held in place, so this part keeps its shape while chains around it can bend.
From: standard chemistry.
Sources and notes
- The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
- The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.
Properties and sources
Calculated by PubChem
- Molecular formula
- C18H19ClN4
- Molecular weight
- 326.8 g/mol
- XLogP3octanol/water, log units
- 3.1
- Polar surface areatopological
- 30.9 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Rotatable bonds
- 1
- Complexity
- 446
Measured LD50, HSDB via PubChem
251 mg/kg pure clozapine, rat, oral
An LD50 is an animal study measurement, not a dose for a person.
Reported Hazard label (GHS), ECHA, HSDB via PubChem
Danger Toxic pictogram (GHS06) and Health hazard pictogram (GHS08); hazard statements H301, H341, H351, H361
Reported Licence
The US Food and Drug Administration licenses Clozapine for human use (NDA 019758, authorized September 26, 1989), as Clozaril. Drugs@FDA
Groups it belongs to
- Category
- Prescription medicine
- Family
- Antipsychotics
- Chemical groups
- Amines, Aromatics, Halogenated
- Hazard classes
- Acutely toxic, Health hazard, GHS Danger
CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42PubChem CID 135398737 · Wikidata Q221361 · InChIKey QZUDBNBUXVUHMW-UHFFFAOYSA-N · Data refreshed
Questions
- What is Clozapine?
- An atypical antipsychotic reserved for schizophrenia that has not responded to anything else, because it demands regular blood monitoring.
- How toxic is Clozapine?
- The reported LD50 of Clozapine is 251 mg/kg (rat, oral). An LD50 is an animal study measurement, not a dose for a person. Its GHS hazard label carries the signal word Danger and the hazard pictograms Toxic and Health hazard. from sourcefrom source
- What kind of molecule is Clozapine?
- Clozapine has the formula C18H19ClN4 and a molecular weight of 326.8 g/mol. MoleculeFinder files it under antipsychotics, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
- Who licenses Clozapine as a medicine?
- The US Food and Drug Administration licenses Clozapine for human use (NDA 019758, authorized September 26, 1989), as Clozaril. from source
Sources and notes
- Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
- LD50from sourceHSDB via PubChemOther values the sources report: rat, intravenous, 41.6 mg/kg; rat, another route, 210 mg/kg; rat, another route, 240 mg/kg. The page shows the one LD50 the site uses everywhere.
- Hazard labelfrom sourceECHA, HSDB via PubChemThe label combines these classifications.
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Licencefrom sourceDrugs@FDARead 2026-10-21.
- Data refreshedfrom sourceMoleculeFinder2026-11-09
Keep exploring
Sources and notes
- The same kind of moleculefrom sourceMoleculeFinder curated groupsA structural neighbour in the same family or type group; the line names the group in its own words.
- The drawingscomputedPubChem structures, drawn by RDKit