Haloperidol
Also called Aloperidin, Brotopon, Eukystol and Halopal.
A first-generation antipsychotic used for schizophrenia, mania and acute agitation. Haloperidol (C21H23ClFNO2, 376 g/mol) is an antipsychotic dispensed on prescription.
Sources and notes
- The introductionfrom sourceMoleculeFinder curated
- Other namesfrom sourcePubChem / Wikidata
- Formula and weightcomputedPubChem
- 2D drawingcomputedPubChem structure, drawn by RDKit
- 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.
Where you encounter it
Dispensed on prescription, not sold on a shelf.
Sources and notes
- The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.
Explore its structure
Choose a part to light it up.
A C=O with a carbon on each side. Its oxygen accepts hydrogen bonds but has no hydrogen to give, and it resists oxidation better than an aldehyde.
From: standard chemistry.
A nitrogen bonded to three carbons, with no hydrogen of its own. Its spare pair of electrons can still pick up a hydrogen ion, so a tertiary amine is a base.
From: standard chemistry.
An O-H on a carbon that is not part of an aromatic ring, the group that makes a molecule an alcohol. It both gives and accepts hydrogen bonds, which helps the molecule mix with water.
From: standard chemistry.
Sources and notes
- The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
- The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.
Properties and sources
Calculated by PubChem
- Molecular formula
- C21H23ClFNO2
- Molecular weight
- 375.9 g/mol
- XLogP3octanol/water, log units
- 3.2
- Polar surface areatopological
- 40.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Rotatable bonds
- 6
- Complexity
- 451
Measured LD50, HSDB via PubChem
165 mg/kg pure haloperidol, rat, oral
An LD50 is an animal study measurement, not a dose for a person.
Reported Hazard label (GHS), ECHA via PubChem
Danger Toxic pictogram (GHS06), Irritant pictogram (GHS07) and Health hazard pictogram (GHS08); hazard statements H301, H315, H317, H319, H335, H361
Reported Licence
The US Food and Drug Administration licenses Haloperidol for human use (NDA 020074). Drugs@FDA
Groups it belongs to
- Category
- Prescription medicine
- Family
- Antipsychotics
- Chemical groups
- Alcohols, Aromatics, Ketones, Halogenated
- Hazard classes
- Acutely toxic, Irritant, Health hazard, GHS Danger
C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)FPubChem CID 3559 · Wikidata Q251347 · InChIKey LNEPOXFFQSENCJ-UHFFFAOYSA-N · Data refreshed
Questions
- What is Haloperidol?
- A first-generation antipsychotic used for schizophrenia, mania and acute agitation. Haloperidol (C21H23ClFNO2, 376 g/mol) is an antipsychotic dispensed on prescription.
- How toxic is Haloperidol?
- The reported LD50 of Haloperidol is 165 mg/kg (rat, oral). An LD50 is an animal study measurement, not a dose for a person. Its GHS hazard label carries the signal word Danger and the hazard pictograms Toxic, Irritant and Health hazard. from sourcefrom source
- What kind of molecule is Haloperidol?
- Haloperidol has the formula C21H23ClFNO2 and a molecular weight of 375.9 g/mol. MoleculeFinder files it under antipsychotics, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
- Who licenses Haloperidol as a medicine?
- The US Food and Drug Administration licenses Haloperidol for human use (NDA 020074). from source
Sources and notes
- Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
- LD50from sourceHSDB via PubChemOther values the sources report: mouse, another route, 60 mg/kg. The page shows the one LD50 the site uses everywhere.
- Hazard labelfrom sourceECHA via PubChemThe label combines these classifications.
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Licencefrom sourceDrugs@FDARead 2026-10-21.
- Data refreshedfrom sourceMoleculeFinder2026-11-09
Keep exploring
Sources and notes
- The same kind of moleculefrom sourceMoleculeFinder curated groupsA structural neighbour in the same family or type group; the line names the group in its own words.
- Similar in shapecomputedRDKit Morgan/TanimotoNeighbours by structural fingerprint; the sentence names the chemical groups the two share.
- The drawingscomputedPubChem structures, drawn by RDKit