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SHEET /m/loperamide · PubChem CID 3955 · CAS 53179-11-6 · REV 2026.07

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Loperamide

from source

C29H33ClN2O2 · 477 g/mol

Imodium · Fortasec · Loperacap · Maalox Anti-Diarrheal

Also sold as Imodium from source

What is Loperamide?

The antidiarrheal sold as Imodium. It is an opioid that acts on the gut but barely reaches the brain. from source

CategoryOTC medicine
Chemical familyAlcoholsAromaticsAmidesHalogenated
LeaderboardsBiggestDeadliest

Fig. 1 · 2D structure RDKit

SMILESCN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4

Where you'll find it

First aid kitwhat else is in it →

Curated by MoleculeFinder from source

Relative acute toxicity from source

Animal study data · LD50

Reported LD50
40 mg/kg · highly toxic
Species
dog
Route
oral

An LD50 describes acute toxicity under experimental conditions and is not a safe or dangerous dose for a person.

Toxicity & hazards

Toxicity · LD50

40 mg/kg · highly toxic · LD50 dog oral from source

2 more reported values
  • 41.5 mg/kgLD50 · oral · guinea pig
  • 2.8 mg/kgLD50 · iv · dog
DangerToxicH301from source

Keep roaming

Where Loperamide leads

Relatedcomputed
Haloperidol45% similarBoth carry an alcohol group.

Sources & methodology

PubChem CID
3955
Wikidata
Q423751
Structure
PubChem → RDKit
LD50
PubChem
Similar molecules
MoleculeFinder fingerprint similarity
Everyday relationships
MoleculeFinder editorial curation
Data refreshed

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