Loperamide from source

C29H33ClN2O2 · 477 g/mol

Loperamida · Loperamidum · Fortasec · 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-

Also sold as Imodium from source

chemical compound

CategoryOTC medicine

Chemical familyAlcohols Aromatics

LeaderboardsBiggest Deadliest

Fig. 1 · 2D structure RDKit

CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4

Where you'll find it

Not yet mapped to everyday foods or products.

The dose makes the poison inferred

A reported dog oral LD50 for Loperamide is 40 mg/kg, the dose lethal to half the animals tested. Scaled by body mass alone:

your weight154 lb

2.8 g

a median lethal dose scaled to 154 lb (2,800 mg)

“The dose makes the poison” is a cross-species estimate shown as neutral science, not a threshold anyone should act on. Real toxicity depends on the person, not body mass alone.

Toxicity & hazards

Toxicity · LD50

40 mg/kg · highly toxic · LD50 dog oral from source

The dose lens above scales this to a body weight.

2 more reported values

41.5 mg/kgLD50 · oral · guinea pig
2.8 mg/kgLD50 · iv · dog

DangerToxicH301from source