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SHEET /m/theophylline · PubChem CID 2153 · CAS 58-55-9 · REV 2026.07

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Theophylline from source

C7H8N4O2 · 180.16 g/mol

1,3-Dimethylxanthine · Elixophyllin · Theophyllin · Theolair

chemical compound

CategoryPlant
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Fig. 1 · 2D structure RDKit

CN1C2=C(C(=O)N(C1=O)C)NC=N2

Where you'll find it

Curated by MoleculeFinder from source

Still in your system computed

Theophylline clears on a half-life of 8 h. Every 8 hours, half of what's left is gone. Put in what you had:

300 mg left
100% of your 300 mg remains

The dose makes the poison inferred

A reported mouse oral LD50 for Theophylline is 332 mg/kg, the dose lethal to half the animals tested. Scaled by body mass alone:

23.2 g77 servings
a median lethal dose scaled to 154 lb (23,240 mg)

“The dose makes the poison” is a cross-species estimate shown as neutral science, not a threshold anyone should act on. Real toxicity depends on the person, not body mass alone.

Signature properties

Half-life8 hfrom source

Toxicity & hazards

Toxicity · LD50

332 mg/kg · low toxicity · LD50 mouse oral from source

The dose lens above scales this to a body weight.

3 more reported values
  • 136 mg/kgLD50 · iv · mouse
  • 180 mg/kgLD50 · other · mouse
  • 271 mg/kgLD50 · other · mouse
DangerToxicIrritantHealth hazardH301, H302, H360, H361, H362, H370, H372, H402from source

Keep roaming

Where Theophylline leads

Theophylline is the third of the three dietary methylxanthines, found in trace amounts in tea and used as a drug to open the airways. It shares caffeine's chemistry but lingers longer in the body.