Clonidine
Also called Catapres-TTS, Catapresan, Catapressan and Chlornidinum.
An alpha-2 agonist used for high blood pressure, ADHD, and withdrawal from opioids and nicotine. Clonidine (C9H9Cl2N3, 230 g/mol) is an alpha-2 agonist dispensed on prescription.
Sources and notes
- The introductionfrom sourceMoleculeFinder curated
- Other namesfrom sourcePubChem / Wikidata
- Formula and weightcomputedPubChem
- 2D drawingcomputedPubChem structure, drawn by RDKit
- 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.
Where you encounter it
Dispensed on prescription, not sold on a shelf.
Sources and notes
- The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.
Explore its structure
Choose a part to light it up.
A carbon bonded to three nitrogens, one of them by a double bond, the same group the amino acid arginine carries. Its N-H groups form hydrogen bonds readily.
From: standard chemistry.
Fluorine, chlorine, bromine or iodine bonded to carbon. Each pulls electrons toward itself, and each is larger than the hydrogen the carbon would otherwise carry.
From: standard chemistry.
Six carbons in a flat hexagon, sharing their electrons evenly around the ring. It is stable, flat and oily, and it stacks readily against other flat rings.
From: standard chemistry.
Sources and notes
- The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
- The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.
Properties and sources
Calculated by PubChem
- Molecular formula
- C9H9Cl2N3
- Molecular weight
- 230.09 g/mol
- XLogP3octanol/water, log units
- 1.6
- Polar surface areatopological
- 36.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 1
- Rotatable bonds
- 2
- Complexity
- 222
Measured LD50, HSDB via PubChem
126 mg/kg pure clonidine, rat, oral
An LD50 is an animal study measurement, not a dose for a person.
Reported Hazard label (GHS), ECHA via PubChem
Danger Toxic pictogram (GHS06); hazard statements H301, H310, H330
Reported Licence
The US Food and Drug Administration licenses Clonidine for human use (NDA 018891, authorized October 10, 1984), as Catapres-TTS-1. Drugs@FDA
Groups it belongs to
- Category
- Prescription medicine
- Family
- Alpha-2 agonists
- Chemical groups
- Amines, Aromatics, Halogenated
- Hazard classes
- Acutely toxic, GHS Danger
C1CN=C(N1)NC2=C(C=CC=C2Cl)ClPubChem CID 2803 · Wikidata Q412221 · InChIKey GJSURZIOUXUGAL-UHFFFAOYSA-N · Data refreshed
Questions
- What is Clonidine?
- An alpha-2 agonist used for high blood pressure, ADHD, and withdrawal from opioids and nicotine. Clonidine (C9H9Cl2N3, 230 g/mol) is an alpha-2 agonist dispensed on prescription.
- How toxic is Clonidine?
- The reported LD50 of Clonidine is 126 mg/kg (rat, oral). An LD50 is an animal study measurement, not a dose for a person. Its GHS hazard label carries the signal word Danger and the hazard pictogram Toxic. from sourcefrom source
- What kind of molecule is Clonidine?
- Clonidine has the formula C9H9Cl2N3 and a molecular weight of 230.09 g/mol. MoleculeFinder files it under alpha-2 agonists, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
- Who licenses Clonidine as a medicine?
- The US Food and Drug Administration licenses Clonidine for human use (NDA 018891, authorized October 10, 1984), as Catapres-TTS-1. from source
Sources and notes
- Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
- LD50from sourceHSDB via PubChemOther values the sources report: rat, intravenous, 29 mg/kg; rat, another route, 77 mg/kg; rat, another route, 100 mg/kg. The page shows the one LD50 the site uses everywhere.
- Hazard labelfrom sourceECHA via PubChemThe label combines these classifications.
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Licencefrom sourceDrugs@FDARead 2026-10-21.
- Data refreshedfrom sourceMoleculeFinder2026-11-09
Keep exploring
Sources and notes
- Similar in shapecomputedRDKit Morgan/TanimotoNeighbours by structural fingerprint; the sentence names the chemical groups the two share.
- The drawingscomputedPubChem structures, drawn by RDKit