Tapentadol
An opioid painkiller that also acts on norepinephrine, used for moderate to severe pain. Tapentadol (C14H23NO, 221 g/mol) is an opioid dispensed on prescription.
Sources and notes
- The introductionfrom sourceMoleculeFinder curated
- Formula and weightcomputedPubChem
- 2D drawingcomputedPubChem structure, drawn by RDKit
- 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.
Where you encounter it
Dispensed on prescription, not sold on a shelf. Tapentadol on the product labels we hold.
Medicines
Every product and list we hold
Sources and notes
- The product labels and their strengthsfrom sourceDailyMed (FDA label)Each label lists the molecule as an ingredient, and an active ingredient at the strength shown.
- How it gets therefrom sourceMoleculeFinder curatedEach mark is set by hand on our lists, never inferred; a label's ingredient is added by the maker. A row with no mark data says Not marked.
- The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.
Explore its structure
Choose a part to light it up.
An O-H fixed directly to a benzene ring. The ring makes that hydrogen easier to give up than an ordinary alcohol's, which is why many phenols act as antioxidants.
From: standard chemistry.
A nitrogen bonded to three carbons, with no hydrogen of its own. Its spare pair of electrons can still pick up a hydrogen ion, so a tertiary amine is a base.
From: standard chemistry.
Six carbons in a flat hexagon, sharing their electrons evenly around the ring. It is stable, flat and oily, and it stacks readily against other flat rings.
From: standard chemistry.
Sources and notes
- The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
- The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.
Properties and sources
Calculated by PubChem
- Molecular formula
- C14H23NO
- Molecular weight
- 221.34 g/mol
- XLogP3octanol/water, log units
- 3.5
- Polar surface areatopological
- 23.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Rotatable bonds
- 5
- Complexity
- 193
Measured LD50, HSDB via PubChem
300 mg/kg pure tapentadol, mouse, oral
An LD50 is an animal study measurement, not a dose for a person.
Reported Hazard label (GHS), ECHA via PubChem
Warning Irritant pictogram (GHS07), Health hazard pictogram (GHS08) and Environmental pictogram (GHS09); hazard statements H302, H361, H411
Reported Licence
The US Food and Drug Administration licenses Tapentadol for human use (NDA 022304, authorized November 20, 2008). Drugs@FDA
Groups it belongs to
- Category
- Prescription medicine
- Family
- Opioids
- Elements
- Nitrogen
- Hazard classes
- Irritant, Health hazard, Environmental hazard, GHS Warning
CC[C@@H](C1=CC(=CC=C1)O)[C@@H](C)CN(C)CPubChem CID 9838022 · Wikidata Q414463 · InChIKey KWTWDQCKEHXFFR-SMDDNHRTSA-N · Data refreshed
Questions
- What is Tapentadol?
- An opioid painkiller that also acts on norepinephrine, used for moderate to severe pain. Tapentadol (C14H23NO, 221 g/mol) is an opioid dispensed on prescription.
- How toxic is Tapentadol?
- The reported LD50 of Tapentadol is 300 mg/kg (mouse, oral). An LD50 is an animal study measurement, not a dose for a person. Its GHS hazard label carries the signal word Warning and the hazard pictograms Irritant, Health hazard and Environmental. from sourcefrom source
- What kind of molecule is Tapentadol?
- Tapentadol has the formula C14H23NO and a molecular weight of 221.34 g/mol. MoleculeFinder files it under opioids, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
- Who licenses Tapentadol as a medicine?
- The US Food and Drug Administration licenses Tapentadol for human use (NDA 022304, authorized November 20, 2008). from source
Sources and notes
- Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
- LD50from sourceHSDB via PubChemOther values the sources report: rat, intravenous, 40 mg/kg. The page shows the one LD50 the site uses everywhere.
- Hazard labelfrom sourceECHA via PubChemThe label combines these classifications.
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Licencefrom sourceDrugs@FDARead 2026-10-21.
- Data refreshedfrom sourceMoleculeFinder2026-11-09
Keep exploring
Sources and notes
- Similar in shapecomputedRDKit Morgan/TanimotoNeighbours by structural fingerprint; the sentence names the chemical groups the two share.
- The drawingscomputedPubChem structures, drawn by RDKit