Amitriptyline

from source

C20H23N · 277.4 g/mol

Adepril · Damilen · Elavil · Flavyl

What is Amitriptyline?

A tricyclic antidepressant now prescribed far more often at low strength for nerve pain, migraine prevention and sleep than for depression. from source

CategoryPrescription medicine

Chemical familyAromatics

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Fig. 1 · 2D structure RDKit

SMILESCN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31

Where you'll find it

Dispensed on prescription, not sold on a shelf. See the rest of the prescription medicine group.

Relative acute toxicity from source

Animal study data · LD50

Reported LD50: 140 mg/kg · moderately toxic
Species: mouse
Route: oral

An LD50 describes acute toxicity under experimental conditions and is not a safe or dangerous dose for a person.

Toxicity & hazards

Toxicity · LD50

140 mg/kg · moderately toxic · LD50 mouse oral from source

4 more reported values

350 mg/kgLD50 · oral · mouse
16 mg/kgLD50 · iv · mouse
56 mg/kgLD50 · other · mouse
140 mg/kgLD50 · other · mouse

DangerCorrosiveToxicIrritantHealth hazardEnvironmentalH301, H302, H311, H318, H331, H361, H410from source

Keep roaming

Where Amitriptyline leads

Compare with

Amitriptyline vs Nortriptyline

Sources & methodology

PubChem CID: 2160
Wikidata: Q58397
Structure: PubChem → RDKit
LD50: PubChem
Similar molecules: MoleculeFinder fingerprint similarity
Data refreshed: September 13, 2026

How MoleculeFinder sources and labels its data