SHEET /m/guaiacol · PubChem CID 460 · CAS 90-05-1 · REV 2026.07
Guaiacol
from sourceC7H8O2 · 124.14 g/mol
Guasol · Pyroguaiac acid · Methoxyphenol · O-Methoxy-Phenol
What is Guaiacol?
The core of smoke flavour. It is what wood smoke deposits on barbecue and smoked fish, and part of the smell of roasted coffee and whisky. Found in coffee and spirits. from source
Fig. 1 · 2D structure RDKit
COC1=CC=CC=C1OWhere you'll find it
Curated by MoleculeFinder from source
The dose makes the poison inferred
A reported rat oral LD50 for Guaiacol is 520 mg/kg, the dose lethal to half the animals tested. Scaled by body mass alone:
“The dose makes the poison” is a cross-species estimate shown as neutral science, not a threshold anyone should act on. Real toxicity depends on the person, not body mass alone.
Toxicity & hazards
Toxicity · LD50
520 mg/kg · low toxicity · LD50 rat oral from source
The dose lens above scales this to a body weight.
2 more reported values
- 621 mg/kgLD50 · oral · mouse
- 725 mg/kgLD50 · oral · rat
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