SHEET /m/guaiacol · PubChem CID 460 · CAS 90-05-1 · REV 2026.07
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Guaiacol from source
C7H8O2 · 124.14 g/mol
2-Methoxyphenol · o-Methoxyphenol · 2-Hydroxyanisole · o-Guaiacol
chemical compound
CategoryScent & aroma
Chemical familyAromatics
Fig. 1 · 2D structure RDKit
COC1=CC=CC=C1O
Where you'll find it
Not yet mapped to everyday foods or products.
The dose makes the poison inferred
A reported rat oral LD50 for Guaiacol is 520 mg/kg, the dose lethal to half the animals tested. Scaled by body mass alone:
36.4 g
a median lethal dose scaled to 154 lb (36,400 mg)
“The dose makes the poison” is a cross-species estimate shown as neutral science, not a threshold anyone should act on. Real toxicity depends on the person, not body mass alone.
Toxicity & hazards
Toxicity · LD50
520 mg/kg · low toxicity · LD50 rat oral from source
The dose lens above scales this to a body weight.
2 more reported values
- 621 mg/kgLD50 · oral · mouse
- 725 mg/kgLD50 · oral · rat
DangerCorrosiveIrritantHealth hazardH302, H315, H318, H319, H332, H336, H370, H402, H412from source
Keep roaming