SHEET /m/nicotine · PubChem CID 89594 · CAS 54-11-5 · REV 2026.07
Nicotine
from sourceC10H14N2 · 162.23 g/mol
Fumetobac · Habitrol · Nicoderm · Nicoderm Cq
What is Nicotine?
The stimulant alkaloid the tobacco plant makes as an insecticide, and the reason tobacco and vaping products are habit-forming. from source
Fig. 1 · 2D structure RDKit
CN1CCC[C@H]1C2=CN=CC=C2Still in the system computed
For a typical adult, Nicotine clears on a half-life of about 2 h: every 2 hours, half of what is left is gone. Try an amount:
An illustration of half-life, not a prediction of anyone's level.
Relative acute toxicity from source
Animal study data · LD50
- Reported LD50
- 188 mg/kg · moderately toxic
- Species
- rat
- Route
- oral
An LD50 describes acute toxicity under experimental conditions and is not a safe or dangerous dose for a person.
Signature properties
Toxicity & hazards
Toxicity · LD50
188 mg/kg · moderately toxic · LD50 rat oral from source
7 more reported values
- 24 mg/kgLD50 · oral · mouse
- 2.8 mg/kgLD50 · iv · rat
- 5.9 mg/kgLD50 · other · mouse
- 25 mg/kgLD50 · other · rat
- 30 mg/kgLD50 · other · rat
- 33.5 mg/kgLD50 · other · rat
- 140 mg/kgLD50 · dermal · rat
Compare with
Nicotine is the stimulant that makes tobacco addictive, and one of the fastest-clearing drugs people use: its half-life is only about two hours, part of why cravings return so quickly. In the plant it is a natural pesticide.