SHEET /m/methotrexate · PubChem CID 126941 · CAS 59-05-2 · REV 2026.07
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Methotrexate
from sourceC20H22N8O5 · 454.4 g/mol
amethopterin · MTX · Antifolan · Emtexate
What is Methotrexate?
A folate blocker used at low strength for rheumatoid arthritis and psoriasis and at high strength as a cancer medicine. from source
CategoryPrescription medicine
Fig. 1 · 2D structure RDKit
SMILES
CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)OWhere you'll find it
Dispensed on prescription, not sold on a shelf. See the rest of the prescription medicine group.
Relative acute toxicity from source
Animal study data · LD50
- Reported LD50
- 43 mg/kg · highly toxic
- Species
- rat
- Route
- oral
An LD50 describes acute toxicity under experimental conditions and is not a safe or dangerous dose for a person.
Toxicity & hazards
Toxicity · LD50
43 mg/kg · highly toxic · LD50 rat oral from source
DangerToxicIrritantHealth hazardH301, H315, H319, H340, H360from source
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