Tramadol
Also called Biomadol, Contramid, Labesfal and Ralivia ER.
An opioid painkiller for moderate pain that also acts on serotonin and norepinephrine, so it behaves partly like an antidepressant.
Sources and notes
- The introductionfrom sourceMoleculeFinder curated
- Other namesfrom sourcePubChem / Wikidata
- Formula and weightcomputedPubChem
- 2D drawingcomputedPubChem structure, drawn by RDKit
- 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.
Where you encounter it
Dispensed on prescription, not sold on a shelf. Tramadol on the product labels we hold.
Medicines
Every product and list we hold
Sources and notes
- The product labels and their strengthsfrom sourceDailyMed (FDA label)Each label lists the molecule as an ingredient, and an active ingredient at the strength shown.
- How it gets therefrom sourceMoleculeFinder curatedEach mark is set by hand on our lists, never inferred; a label's ingredient is added by the maker. A row with no mark data says Not marked.
- The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.
Explore its structure
Choose a part to light it up.
A nitrogen bonded to three carbons, with no hydrogen of its own. Its spare pair of electrons can still pick up a hydrogen ion, so a tertiary amine is a base.
From: standard chemistry.
An O-H on a carbon that is not part of an aromatic ring, the group that makes a molecule an alcohol. It both gives and accepts hydrogen bonds, which helps the molecule mix with water.
From: standard chemistry.
An oxygen bridging two carbons, written C-O-C. It accepts hydrogen bonds but has no hydrogen to give, and it is slow to react.
From: standard chemistry.
Sources and notes
- The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
- The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.
Compare a related molecule
Tramadol
Oxycodone
Oxycodone, sold as Oxycontin, is a plain opioid close to morphine; tramadol binds the opioid receptor weakly and also acts on serotonin and norepinephrine.
Tramadol vs Oxycodone, side by sideAlso compared
Sources and notes
- The sentencefrom sourceMoleculeFinder comparison notesThe pair's answer line.
- The two drawingscomputedPubChem structures, drawn by RDKitThe two drawings side by side.
Properties and sources
Calculated by PubChem
- Molecular formula
- C16H25NO2
- Molecular weight
- 263.37 g/mol
- XLogP3octanol/water, log units
- 2.6
- Polar surface areatopological
- 32.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Rotatable bonds
- 4
- Complexity
- 282
Measured LD50, HSDB via PubChem
228 mg/kg pure tramadol, rat, oral
An LD50 is an animal study measurement, not a dose for a person.
Reported Hazard label (GHS), ECHA, HSDB via PubChem
Danger Toxic pictogram (GHS06), Irritant pictogram (GHS07) and Environmental pictogram (GHS09); hazard statements H300, H301, H302, H312, H315, H319, H331, H332, H335, H336, H401, H411
Reported Licence
The US Food and Drug Administration licenses Tramadol for human use (NDA 022370, authorized May 7, 2010), as Conzip. Drugs@FDA
Groups it belongs to
- Category
- Prescription medicine
- Family
- Opioids
- Elements
- Nitrogen
- Hazard classes
- Acutely toxic, Irritant, Environmental hazard, GHS Danger
CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)OPubChem CID 33741 · Wikidata Q407592 · InChIKey TVYLLZQTGLZFBW-ZBFHGGJFSA-N · Data refreshed
Questions
- What is Tramadol?
- An opioid painkiller for moderate pain that also acts on serotonin and norepinephrine, so it behaves partly like an antidepressant.
- How toxic is Tramadol?
- The reported LD50 of Tramadol is 228 mg/kg (rat, oral). An LD50 is an animal study measurement, not a dose for a person. Its GHS hazard label carries the signal word Danger and the hazard pictograms Toxic, Irritant and Environmental. from sourcefrom source
- What kind of molecule is Tramadol?
- Tramadol has the formula C16H25NO2 and a molecular weight of 263.37 g/mol. MoleculeFinder files it under opioids, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
- Who licenses Tramadol as a medicine?
- The US Food and Drug Administration licenses Tramadol for human use (NDA 022370, authorized May 7, 2010), as Conzip. from source
Sources and notes
- Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
- LD50from sourceHSDB via PubChemOther values the sources report: mouse, oral, 270 mg/kg; mouse, intravenous, 60.45 mg/kg; mouse, another route, 200 mg/kg. The page shows the one LD50 the site uses everywhere.
- Hazard labelfrom sourceECHA, HSDB via PubChemThe label combines these classifications.
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Licencefrom sourceDrugs@FDARead 2026-10-21.
- Data refreshedfrom sourceMoleculeFinder2026-11-09
Keep exploring
Sources and notes
- Compared side by sidefrom sourceMoleculeFinder comparison notesA molecule we compare it with on its own page.
- Similar in shapecomputedRDKit Morgan/TanimotoNeighbours by structural fingerprint; the sentence names the chemical groups the two share.
- The drawingscomputedPubChem structures, drawn by RDKit