moleculefinder

Lidocaine

C14H22N2O234.34 g/mol Calculated

Also called xylocaine.

The local anaesthetic behind a numbed tooth, sold as Xylocaine, and the active ingredient in over-the-counter numbing creams and patches.

Sources and notes
  • The introductionfrom sourceMoleculeFinder curated
  • Other namesfrom sourceWikidataIts English label and aliases on Wikidata.
  • Formula and weightcomputedPubChem
  • 2D drawingcomputedPubChem structure, drawn by RDKit
  • 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.

Where you encounter it

Dispensed on prescription, not sold on a shelf. Lidocaine on the product labels we hold.

Medicines

AspercremeAdded by the makerActive ingredient, 4%
Icy HotAdded by the makerActive ingredient, 4%
Solarcaine Burn ReliefAdded by the makerActive ingredient, 4%
XylocaineAdded by the makerActive ingredient

Household

Bactine MaxAdded by the makerActive ingredient, 4%

Every product and list we hold

Sources and notes
  • The product labels and their strengthsfrom sourceDailyMed (FDA label)Each label lists the molecule as an ingredient, and an active ingredient at the strength shown.
  • How it gets therefrom sourceMoleculeFinder curatedEach mark is set by hand on our lists, never inferred; a label's ingredient is added by the maker. A row with no mark data says Not marked.
  • The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.

Explore its structure

Choose a part to light it up.

A C=O bonded to a nitrogen, the same link that joins amino acids in a protein. It is sturdy, and its nitrogen is not a base the way an amine's is.

From: standard chemistry.

Sources and notes
  • The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
  • The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.

Properties and sources

Calculated by PubChem

Molecular formula
C14H22N2O
Molecular weight
234.34 g/mol
XLogP3octanol/water, log units
2.3
Polar surface areatopological
32.3 Ų
H-bond donors
1
H-bond acceptors
2
Rotatable bonds
5
Complexity
228

Measured LD50, HSDB via PubChem

317 mg/kg pure lidocaine, rat, oral

An LD50 is an animal study measurement, not a dose for a person.

Reported Hazard label (GHS), ECHA, HSDB via PubChem

Warning Irritant pictogram (GHS07); hazard statements H302

Reported Licence

The US Food and Drug Administration licenses Lidocaine for human use (NDA 006488, authorized November 19, 1948). Drugs@FDA

Groups it belongs to

Category
Prescription medicine
Family
Anaesthetics
Use
Skin and topical
Chemical groups
Aromatics, Amides
Elements
Nitrogen
Hazard classes
Irritant, GHS Warning
SMILESCCN(CC)CC(=O)NC1=C(C=CC=C1C)C

PubChem CID 3676 · Wikidata Q216935 · InChIKey NNJVILVZKWQKPM-UHFFFAOYSA-N · Data refreshed

How MoleculeFinder sources and labels its data

Questions
What is Lidocaine?
The local anaesthetic behind a numbed tooth, sold as Xylocaine, and the active ingredient in over-the-counter numbing creams and patches.
How toxic is Lidocaine?
The reported LD50 of Lidocaine is 317 mg/kg (rat, oral). An LD50 is an animal study measurement, not a dose for a person. Its GHS hazard label carries the signal word Warning and the hazard pictogram Irritant. from sourcefrom source
What kind of molecule is Lidocaine?
Lidocaine has the formula C14H22N2O and a molecular weight of 234.34 g/mol. MoleculeFinder files it under anaesthetics, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
What else is Lidocaine called?
Lidocaine is also called xylocaine. from source
Who licenses Lidocaine as a medicine?
The US Food and Drug Administration licenses Lidocaine for human use (NDA 006488, authorized November 19, 1948). from source
Sources and notes
  • Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
  • LD50from sourceHSDB via PubChemOther values the sources report: mouse, oral, 292 mg/kg; mouse, intravenous, 19.5 mg/kg; mouse, another route, 105 mg/kg. The page shows the one LD50 the site uses everywhere.
  • Hazard labelfrom sourceECHA, HSDB via PubChemThe label combines these classifications.
  • ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
  • Licencefrom sourceDrugs@FDARead 2026-10-21.
  • Data refreshedfrom sourceMoleculeFinder2026-11-09