moleculefinder

Tacrolimus

C44H69NO12804 g/mol Calculated

Also called fujimycin.

An immunosuppressant from a Japanese soil bacterium, used to stop organ rejection after transplant and as an eczema ointment.

Sources and notes
  • The introductionfrom sourceMoleculeFinder curated
  • Other namesfrom sourceWikidataIts English label and aliases on Wikidata.
  • Formula and weightcomputedPubChem
  • 2D drawingcomputedPubChem structure, drawn by RDKit

Where you encounter it

Dispensed on prescription, not sold on a shelf. Tacrolimus on the product labels we hold.

Medicines

PrografAdded by the makerActive ingredient

Every product and list we hold

Sources and notes
  • The product labels and their strengthsfrom sourceDailyMed (FDA label)Each label lists the molecule as an ingredient, and an active ingredient at the strength shown.
  • How it gets therefrom sourceMoleculeFinder curatedEach mark is set by hand on our lists, never inferred; a label's ingredient is added by the maker. A row with no mark data says Not marked.
  • The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.

Explore its structure

Choose a part to light it up.

An ester closed into a ring: the C=O carbon and the oxygen beside it are both ring atoms. Like any ester, it can be split by water, which opens the ring.

From: standard chemistry.

Sources and notes
  • The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
  • The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.

Properties and sources

Calculated by PubChem

Molecular formula
C44H69NO12
Molecular weight
804 g/mol
XLogP3octanol/water, log units
2.7
Polar surface areatopological
178 Ų
H-bond donors
3
H-bond acceptors
12
Rotatable bonds
7
Complexity
1480

Measured LD50, HSDB via PubChem

134 mg/kg pure tacrolimus, rat, oral

An LD50 is an animal study measurement, not a dose for a person.

Reported Hazard label (GHS), ECHA, HSDB via PubChem

Danger Toxic pictogram (GHS06) and Health hazard pictogram (GHS08); hazard statements H301, H361, H372

Reported Licence

The US Food and Drug Administration licenses Tacrolimus for human use (NDA 050708, authorized April 8, 1994), as Prograf. Drugs@FDA

Groups it belongs to

Category
Prescription medicine
Family
Immunosuppressants
Chemical groups
Alcohols, Ketones, Esters, Amides, Ethers
Elements
Nitrogen
Hazard classes
Acutely toxic, Health hazard, GHS Danger
SMILESC[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(…176 characters

PubChem CID 445643 · Wikidata Q411648 · InChIKey QJJXYPPXXYFBGM-LFZNUXCKSA-N · Data refreshed

How MoleculeFinder sources and labels its data

Questions
What is Tacrolimus?
An immunosuppressant from a Japanese soil bacterium, used to stop organ rejection after transplant and as an eczema ointment.
How toxic is Tacrolimus?
The reported LD50 of Tacrolimus is 134 mg/kg (rat, oral). An LD50 is an animal study measurement, not a dose for a person. Its GHS hazard label carries the signal word Danger and the hazard pictograms Toxic and Health hazard. from sourcefrom source
What kind of molecule is Tacrolimus?
Tacrolimus has the formula C44H69NO12 and a molecular weight of 804 g/mol. MoleculeFinder files it under immunosuppressants, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
What else is Tacrolimus called?
Tacrolimus is also called fujimycin. from source
Who licenses Tacrolimus as a medicine?
The US Food and Drug Administration licenses Tacrolimus for human use (NDA 050708, authorized April 8, 1994), as Prograf. from source
Sources and notes
  • Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
  • LD50from sourceHSDB via PubChemOther values the sources report: rat, intravenous, 23.6 mg/kg. The page shows the one LD50 the site uses everywhere.
  • Hazard labelfrom sourceECHA, HSDB via PubChemThe label combines these classifications.
  • ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
  • Licencefrom sourceDrugs@FDARead 2026-10-21.
  • Data refreshedfrom sourceMoleculeFinder2026-11-09

Keep exploring

Also an immunosuppressantSirolimusC51H79NO13
Sources and notes
  • The same kind of moleculefrom sourceMoleculeFinder curated groupsA structural neighbour in the same family or type group; the line names the group in its own words.
  • The drawingscomputedPubChem structures, drawn by RDKit