SHEET /m/safrole · PubChem CID 5144 · CAS 94-59-7 · REV 2026.07
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Safrole from source
C10H10O2 · 162.18 g/mol
Safrol · Shikimole · Shikomol · 5-Allyl-1,3-benzodioxole
chemical compound
CategoryPlant
Chemical familyAromatics
Fig. 1 · 2D structure RDKit
C=CCC1=CC2=C(C=C1)OCO2
Where you'll find it
Not yet mapped to everyday foods or products.
The dose makes the poison inferred
A reported rat oral LD50 for Safrole is 1,950 mg/kg, the dose lethal to half the animals tested. Scaled by body mass alone:
136.5 g
a median lethal dose scaled to 154 lb (136,500 mg)
“The dose makes the poison” is a cross-species estimate shown as neutral science, not a threshold anyone should act on. Real toxicity depends on the person, not body mass alone.
Toxicity & hazards
Toxicity · LD50
1,950 mg/kg · low toxicity · LD50 rat oral from source
The dose lens above scales this to a body weight.
3 more reported values
- 2,350 mg/kgLD50 · oral · mouse
- 1,020 mg/kgLD50 · other · mouse
- 5,000 mg/kgLD50 · dermal · rabbit
DangerIrritantHealth hazardH302, H315, H341, H350, H351, H371, H373from source
Keep roaming
Where Safrole leads
Relatedcomputed