Safest
from sourcecomputed
The Deadliest board read the other way: ranked by the HIGHEST reported oral LD50, so the molecules that take the largest dose per kilogram of body weight to do harm come first. Same oral-only rule and the same route and species on every row. A high LD50 means an animal study found a large dose tolerable, nothing more: it is not a safety rating and not advice.
#MoleculeLD50RouteRelative
01Oleic acidC18H34O274,000 mg/kgoral · rat02SucroseC12H22O1129,700 mg/kgoral · rat03PiracetamC6H10N2O226,000 mg/kgoral · mouse04GlucoseC6H12O625,800 mg/kgoral · rat05PhylloquinoneC31H46O225,000 mg/kgoral · mouse06Silicon dioxideO2Si22,500 mg/kgoral · rat07Propylene glycolC3H8O222,000 mg/kgoral · rat08Erucic acidC22H42O219,431.7 mg/kgoral · rat09Disodium phosphateHNa2O4P17,000 mg/kgoral · rat10SorbitolC6H14O615,900 mg/kgoral · rat11ClonazepamC15H10ClN3O315,000 mg/kgoral · rat12DexpanthenolC9H19NO415,000 mg/kgoral · mouse13SaccharinC7H5NO3S14,200 mg/kgoral · rat14IodineI214,000 mg/kgoral · rat15MannitolC6H14O613,500 mg/kgoral · rat16Lauric acidC12H24O212,000 mg/kgoral · rat17Sorbic acidC6H8O210,500 mg/kgoral · rat18CarbonC10,000 mg/kgoral · rat19BiotinC10H16N2O3S10,000 mg/kgoral · mouse20AciclovirC8H11N5O310,000 mg/kgoral · mouse21RiboflavinC17H20N4O610,000 mg/kgoral · rat22Myristic acidC14H28O210,000 mg/kgoral · rat23ErythromycinC37H67NO139,272 mg/kgoral · rat24Sodium hypochloriteClNaO8,910 mg/kgoral · rat25Butyric acidC4H8O28,790 mg/kgoral · rat26UreaCH4N2O8,471 mg/kgoral · rat27Benzoyl peroxideC14H10O47,710 mg/kgoral · rat28GlutamineC5H10N2O37,500 mg/kgoral · rat29Isoamyl acetateC7H14O27,422 mg/kgoral · rabbit30AntimonySb7,000 mg/kgoral · rat31TaurineC2H7NO3S7,000 mg/kgoral · rat32Nicotinic acidC6H5NO27,000 mg/kgoral · rat33Calcium carbonateCCaO36,450 mg/kgoral · rat34SulfamethoxazoleC10H11N3O3S6,370 mg/kgoral · rat35CobaltCo6,171 mg/kgoral · rat36NorethisteroneC20H26O26,000 mg/kgoral · mouse374-Aminobenzoic acidC7H7NO26,000 mg/kgoral · rat38AcetoneC3H6O5,800 mg/kgoral · rat39MethanolCH4O5,628 mg/kgoral · rat40GlycerolC3H8O35,570 mg/kgoral · rat41LevonorgestrelC21H28O25,010 mg/kgoral · rat42LimoneneC10H165,000 mg/kgoral · rat43Vitamin CC6H8O65,000 mg/kgoral · rat44LoratadineC22H23ClN2O25,000 mg/kgoral · rat45Aluminium oxideAl2O35,000 mg/kgoral · rat46VancomycinC66H75Cl2N9O245,000 mg/kgoral · mouse47HexaneC6H145,000 mg/kgoral · mouse48Azelaic acidC9H16O45,000 mg/kgoral · rat49OxazepamC15H11ClN2O25,000 mg/kgoral · rat50SqualeneC30H505,000 mg/kgoral · mouse51Aluminium hydroxideAlH3O35,000 mg/kgoral · rat52Calcium gluconateC12H22CaO145,000 mg/kgoral · rat53Gallic acidC7H6O55,000 mg/kgoral · rabbit54MyrceneC10H165,000 mg/kgoral · rat55ChlorhexidineC22H30Cl2N105,000 mg/kgoral · rat56Potassium sorbateC6H7KO24,920 mg/kgoral · rat57Ethyl acetateC4H8O24,900 mg/kgoral · rabbit58Isopropyl alcoholC3H8O4,797 mg/kgoral · dog59Ethylene glycolC2H6O24,700 mg/kgoral · rat60β-IononeC13H20O4,590 mg/kgoral · rat61Sodium bicarbonateCHNaO34,220 mg/kgoral · rat62OmeprazoleC17H19N3O3S4,000 mg/kgoral · rat63Lactic acidC3H6O33,730 mg/kgoral · rat64Ethylenediaminetetraacetic acidC10H16N2O83,700 mg/kgoral · rat65α-PineneC10H163,700 mg/kgoral · rat66TriclosanC12H7Cl3O23,700 mg/kgoral · rat67GeraniolC10H18O3,600 mg/kgoral · rat68Acetic acidC2H4O23,530 mg/kgoral · rat69Methylene blueC16H18ClN3S3,500 mg/kgoral · mouse70NicotinamideC6H6N2O3,500 mg/kgoral · rat71Sodium acetateC2H3NaO23,500 mg/kgoral · rat72Sodium benzoateC7H5NaO23,450 mg/kgoral · rat73CinnamaldehydeC9H8O3,400 mg/kgoral · rat74Choline chlorideC5H14ClNO3,400 mg/kgoral · rat75BenzeneC6H63,306 mg/kgoral · rat76MentholC10H20O3,300 mg/kgoral · rat77Dimethyl sulfideC2H6S3,300 mg/kgoral · rat78SiliconSi3,160 mg/kgoral · rat79Potassium nitrateKNO33,015 mg/kgoral · rat80Sodium chlorideClNa3,000 mg/kgoral · rat81Citric acidC6H8O73,000 mg/kgoral · rat82AcetylcysteineC5H9NO3S3,000 mg/kgoral · rat83Malic acidC4H6O53,000 mg/kgoral · rabbit84AtenololC14H22N2O33,000 mg/kgoral · rat85BisacodylC22H19NO43,000 mg/kgoral · rat86Zinc sulfateO4SZn2,949 mg/kgoral · rat87Methyl anthranilateC8H9NO22,910 mg/kgoral · rat88Sodium carbonateCNa2O32,800 mg/kgoral · rat89LinaloolC10H18O2,790 mg/kgoral · rat90PiperonalC8H6O32,700 mg/kgoral · rat91BoraxB4Na2O72,660 mg/kgoral · rat92DocusateC20H37NaO7S2,640 mg/kgoral · mouse93Propionic acidC3H6O22,600 mg/kgoral · rat94RetinolC20H30O2,570 mg/kgoral · mouse95SirolimusC51H79NO132,500 mg/kgoral · mouse96EucalyptolC10H18O2,480 mg/kgoral · rat97AcetaminophenC8H9NO22,400 mg/kgoral · rat98Succinic acidC4H6O42,260 mg/kgoral · rat99Phenylacetic acidC8H8O22,250 mg/kgoral · rat100Sulfuric acidH2O4S2,140 mg/kgoral · rat101AcetophenoneC8H8O2,081 mg/kgoral · rat102Brilliant blue FCFC37H34N2Na2O9S32,000 mg/kgoral · rat103CandesartanC24H20N6O32,000 mg/kgoral · rat104TretinoinC20H28O21,960 mg/kgoral · rat105SafroleC10H10O21,950 mg/kgoral · rat106Glycolic acidC2H4O31,950 mg/kgoral · rat107Benzoic acidC7H6O21,940 mg/kgoral · mouse108EugenolC10H12O21,930 mg/kgoral · rat109BenzophenoneC13H10O1,900 mg/kgoral · rat110DEETC12H17NO1,892 mg/kgoral · rat111CysteineC3H7NO2S1,890 mg/kgoral · rat112QuinineC20H24N2O21,800 mg/kgoral · guinea pig113ProchlorperazineC20H24ClN3S1,800 mg/kgoral · rat114L-DOPAC9H11NO41,780 mg/kgoral · rat115Benzyl benzoateC14H12O21,700 mg/kgoral · rat116Ammonium chlorideClH4N1,650 mg/kgoral · rat117CarvoneC10H14O1,640 mg/kgoral · rat118PhenytoinC15H12N2O21,635 mg/kgoral · rat119FuraneolC6H8O31,608 mg/kgoral · mouse120MidazolamC18H13ClFN31,600 mg/kgoral · rat121DichloromethaneCH2Cl21,600 mg/kgoral · rat122VanillinC8H8O31,580 mg/kgoral · rat123GlyphosateC3H8NO5P1,568 mg/kgoral · mouse124Phosphoric acidH3O4P1,530 mg/kgoral · rat125ChloramphenicolC11H12Cl2N2O51,500 mg/kgoral · mouse126CiclosporinC62H111N11O121,489 mg/kgoral · rat127NaltrexoneC20H23NO41,450 mg/kgoral · rat128Caprylic acidC8H16O21,410 mg/kgoral · rat129MaltolC6H6O31,410 mg/kgoral · guinea pig130Raspberry ketoneC10H12O21,320 mg/kgoral · rat131CamphorC10H16O1,310 mg/kgoral · mouse132BenzaldehydeC7H6O1,300 mg/kgoral · rat133Isoamyl alcoholC5H12O1,300 mg/kgoral · rat134Sodium lauryl sulfateC12H25NaO4S1,288 mg/kgoral · rat135ClarithromycinC38H69NO131,270 mg/kgoral · rat136Sodium nitrateNNaO31,267 mg/kgoral · rat137NaproxenC14H14O31,234 mg/kgoral · mouse138AlprazolamC17H13ClN41,220 mg/kgoral · rat139MethylglyoxalC3H4O21,165 mg/kgoral · rat140BisoprololC18H31NO41,112 mg/kgoral · rat141ValproateC8H16O21,098 mg/kgoral · mouse142NifedipineC17H18N2O61,022 mg/kgoral · rat143MetforminC4H11N51,000 mg/kgoral · rat144ThymolC10H14O980 mg/kgoral · rat145Salicylic acidC7H6O3891 mg/kgoral · rat146Butylated hydroxytolueneC15H24O890 mg/kgoral · rat147Methyl salicylateC8H8O3887 mg/kgoral · rat148RopiniroleC16H24N2O862 mg/kgoral · rat149HydroxyzineC21H27ClN2O2840 mg/kgoral · rat150Magnesium oxideMgO810 mg/kgoral · mouse151MeprobamateC9H18N2O4794 mg/kgoral · rat152ArsenicAs763 mg/kgoral · rat153MetoclopramideC14H22ClN3O2750 mg/kgoral · rat154Potassium permanganateKMnO4750 mg/kgoral · rat155DiazepamC16H13ClN2O710 mg/kgoral · rat156Formic acidCH2O2700 mg/kgoral · mouse157TrazodoneC19H22ClN5O690 mg/kgoral · rat158EthanethiolC2H6S682 mg/kgoral · rat159MidodrineC12H18N2O4675 mg/kgoral · mouse160AcetaldehydeC2H4O661 mg/kgoral · rat161PhenobarbitalC12H12N2O3660 mg/kgoral · rat162IbuprofenC13H18O2636 mg/kgoral · rat163ZincZn630 mg/kgoral · rat164Tert-ButylhydroquinoneC10H14O2615 mg/kgoral · rat165NitrofurantoinC8H6N4O5604 mg/kgoral · rat166BupropionC13H18ClNO600 mg/kgoral · rat167EphedrineC10H15NO600 mg/kgoral · rat168PermethrinC21H20Cl2O3600 mg/kgoral · rat169PromethazineC17H20N2S580 mg/kgoral · rabbit170DoxorubicinC27H29NO11570 mg/kgoral · mouse171GuaiacolC7H8O2520 mg/kgoral · rat172DiclofenacC14H11Cl2NO2500 mg/kgoral · dog173DisulfiramC10H20N2S4500 mg/kgoral · rat174TrimethylamineC3H9N500 mg/kgoral · rat175Chloral hydrateC2H3Cl3O2479 mg/kgoral · rat176CodeineC18H21NO3427 mg/kgoral · rat177CyclobenzaprineC20H21N425 mg/kgoral · rat178FlunitrazepamC16H12FN3O3415 mg/kgoral · rat179NortriptylineC19H21N387 mg/kgoral · mouse180Potassium chlorideClK383 mg/kgoral · mouse181HydrocodoneC18H21NO3375 mg/kgoral · rat182MorphineC17H19NO3335 mg/kgoral · rat183TheophyllineC7H8N4O2332 mg/kgoral · mouse184Iron(II) sulfateFeO4S319 mg/kgoral · rat185LidocaineC14H22N2O317 mg/kgoral · rat186PhenolC6H6O317 mg/kgoral · rat187TapentadolC14H23NO300 mg/kgoral · mouse188TheobromineC7H8N4O2300 mg/kgoral · dog189Copper(II) sulfateCuO4S300 mg/kgoral · rat190ApomorphineC17H17NO2300 mg/kgoral · mouse191CoumarinC9H6O2293 mg/kgoral · rat192Potassium hydroxideHKO273 mg/kgoral · rat193ClozapineC18H19ClN4251 mg/kgoral · rat194ImipramineC19H24N2250 mg/kgoral · rat195AmobarbitalC11H18N2O3250 mg/kgoral · rat196DiacetylC4H6O2250 mg/kgoral · mouse197TramadolC16H25NO2228 mg/kgoral · rat198CadmiumCd225 mg/kgoral · rat199DextromethorphanC18H25NO201 mg/kgoral · mouse200AspirinC9H8O4200 mg/kgoral · rat201CaffeineC8H10N4O2192 mg/kgoral · rat202MethylphenidateC14H19NO2190 mg/kgoral · mouse203NicotineC10H14N2188 mg/kgoral · rat204Sodium nitriteNNaO2175 mg/kgoral · mouse205HaloperidolC21H23ClFNO2165 mg/kgoral · rat206PethidineC15H21NO2162 mg/kgoral · rat207QuercetinC15H10O7161 mg/kgoral · rat208CyclophosphamideC7H15Cl2N2O2P160 mg/kgoral · rat209Perfluorooctanesulfonic acidC8HF17O3S154 mg/kgoral · rat210DoxepinC19H21NO147 mg/kgoral · rat211ChlorpromazineC17H19ClN2S142 mg/kgoral · rat212AmitriptylineC20H23N140 mg/kgoral · mouse213TacrolimusC44H69NO12134 mg/kgoral · rat214FurfuralC5H4O2127 mg/kgoral · rat215ClonidineC9H9Cl2N3126 mg/kgoral · rat216SecobarbitalC12H18N2O3125 mg/kgoral · rat217AcrylamideC3H5NO124 mg/kgoral · rat218PentobarbitalC11H18N2O3118 mg/kgoral · rat219FluorouracilC4H3FN2O2115 mg/kgoral · mouse220VerapamilC27H38N2O4114 mg/kgoral · rat221Allyl isothiocyanateC4H5NS112 mg/kgoral · rat222FormaldehydeCH2O100 mg/kgoral · rat223MethadoneC21H27NO86 mg/kgoral · rat224TelluriumTe83 mg/kgoral · rat225MethanethiolCH4S61 mg/kgoral · mouse226CapsaicinC18H27NO347.2 mg/kgoral · mouse227Sodium fluorideFNa44.3 mg/kgoral · mouse228LoperamideC29H33ClN2O240 mg/kgoral · dog229DextroamphetamineC9H13N38 mg/kgoral · rat230AmphetamineC9H13N22 mg/kgoral · mouse231NorepinephrineC8H11NO320 mg/kgoral · mouse232FentanylC22H28N2O18 mg/kgoral · rat233DigoxinC41H64O1417.78 mg/kgoral · mouse234IndometacinC19H16ClNO412 mg/kgoral · rat235ColchicineC22H25NO65.89 mg/kgoral · mouse← All leaderboards · values carry source citations; the ranking regenerates on every ETL run from source