SHEET /best/safest · LEADERBOARD
Safest
from sourcecomputed
The Deadliest board read the other way: ranked by the HIGHEST reported oral LD50, so the molecules that take the largest dose per kilogram of body weight to do harm come first. Same oral-only rule and the same route and species on every row. A high LD50 means an animal study found a large dose tolerable, nothing more: it is not a safety rating and not advice.
#MoleculeLD50RouteRelative
01Oleic acidC18H34O274,000 mg/kgoral · rat02SucroseC12H22O1129,700 mg/kgoral · rat03GlucoseC6H12O625,800 mg/kgoral · rat04PhylloquinoneC31H46O225,000 mg/kgoral · mouse05Silicon dioxideO2Si22,500 mg/kgoral · rat06Propylene glycolC3H8O222,000 mg/kgoral · rat07Erucic acidC22H42O219,431.7 mg/kgoral · rat08Disodium phosphateHNa2O4P17,000 mg/kgoral · rat09SorbitolC6H14O615,900 mg/kgoral · rat10ClonazepamC15H10ClN3O315,000 mg/kgoral · rat11DexpanthenolC9H19NO415,000 mg/kgoral · mouse12SaccharinC7H5NO3S14,200 mg/kgoral · rat13IodineI214,000 mg/kgoral · rat14MannitolC6H14O613,500 mg/kgoral · rat15Lauric acidC12H24O212,000 mg/kgoral · rat16Sorbic acidC6H8O210,500 mg/kgoral · rat17CarbonC10,000 mg/kgoral · rat18BiotinC10H16N2O3S10,000 mg/kgoral · mouse19AciclovirC8H11N5O310,000 mg/kgoral · mouse20RiboflavinC17H20N4O610,000 mg/kgoral · rat21Myristic acidC14H28O210,000 mg/kgoral · rat22ErythromycinC37H67NO139,272 mg/kgoral · rat23ManganeseMn9,000 mg/kgoral · rat24Sodium hypochloriteClNaO8,910 mg/kgoral · rat25Butyric acidC4H8O28,790 mg/kgoral · rat26UreaCH4N2O8,471 mg/kgoral · rat27GabapentinC9H17NO28,000 mg/kgoral · rat28Benzoyl peroxideC14H10O47,710 mg/kgoral · rat29GlutamineC5H10N2O37,500 mg/kgoral · rat30Isoamyl acetateC7H14O27,422 mg/kgoral · rabbit31AntimonySb7,000 mg/kgoral · rat32TaurineC2H7NO3S7,000 mg/kgoral · rat33Nicotinic acidC6H5NO27,000 mg/kgoral · rat34SeleniumSe6,700 mg/kgoral · rat35Calcium carbonateCCaO36,450 mg/kgoral · rat36CobaltCo6,171 mg/kgoral · rat374-Aminobenzoic acidC7H7NO26,000 mg/kgoral · rat38AcetoneC3H6O5,800 mg/kgoral · rat39EthanolC2H6O5,628 mg/kgoral · rat40MethanolCH4O5,628 mg/kgoral · rat41GlycerolC3H8O35,570 mg/kgoral · rat42LimoneneC10H165,000 mg/kgoral · rat43Vitamin CC6H8O65,000 mg/kgoral · rat44LoratadineC22H23ClN2O25,000 mg/kgoral · rat45TolueneC7H85,000 mg/kgoral · rat46Aluminium oxideAl2O35,000 mg/kgoral · rat47VancomycinC66H75Cl2N9O245,000 mg/kgoral · mouse48HexaneC6H145,000 mg/kgoral · mouse49SqualeneC30H505,000 mg/kgoral · mouse50Aluminium hydroxideAlH3O35,000 mg/kgoral · rat51Calcium gluconateC12H22CaO145,000 mg/kgoral · rat52Gallic acidC7H6O55,000 mg/kgoral · rabbit53MyrceneC10H165,000 mg/kgoral · rat54ChlorhexidineC22H30Cl2N105,000 mg/kgoral · rat55Potassium sorbateC6H7KO24,920 mg/kgoral · rat56Ethyl acetateC4H8O24,900 mg/kgoral · rabbit57Isopropyl alcoholC3H8O4,797 mg/kgoral · dog58Ethylene glycolC2H6O24,700 mg/kgoral · rat59β-IononeC13H20O4,590 mg/kgoral · rat60Sodium bicarbonateCHNaO34,220 mg/kgoral · rat61OmeprazoleC17H19N3O3S4,000 mg/kgoral · rat62MiconazoleC18H14Cl4N2O3,800 mg/kgoral · mouse63Lactic acidC3H6O33,730 mg/kgoral · rat64ThiamineC12H17N4OS+3,710 mg/kgoral · rat65Ethylenediaminetetraacetic acidC10H16N2O83,700 mg/kgoral · rat66α-PineneC10H163,700 mg/kgoral · rat67TriclosanC12H7Cl3O23,700 mg/kgoral · rat68MethoxyfluraneC3H4Cl2F2O3,600 mg/kgoral · rat69GeraniolC10H18O3,600 mg/kgoral · rat70Acetic acidC2H4O23,530 mg/kgoral · rat71Methylene blueC16H18ClN3S3,500 mg/kgoral · mouse72NicotinamideC6H6N2O3,500 mg/kgoral · rat73Sodium acetateC2H3NaO23,500 mg/kgoral · rat74Sodium benzoateC7H5NaO23,450 mg/kgoral · rat75CinnamaldehydeC9H8O3,400 mg/kgoral · rat76Choline chlorideC5H14ClNO3,400 mg/kgoral · rat77BenzeneC6H63,306 mg/kgoral · rat78MentholC10H20O3,300 mg/kgoral · rat79Dimethyl sulfideC2H6S3,300 mg/kgoral · rat80MelatoninC13H16N2O23,200 mg/kgoral · rat81LorazepamC15H10Cl2N2O23,178 mg/kgoral · mouse82MelamineC3H6N63,161 mg/kgoral · rat83SiliconSi3,160 mg/kgoral · rat84Potassium nitrateKNO33,015 mg/kgoral · rat85Sodium chlorideClNa3,000 mg/kgoral · rat86Citric acidC6H8O73,000 mg/kgoral · rat87AcetylcysteineC5H9NO3S3,000 mg/kgoral · rat88Malic acidC4H6O53,000 mg/kgoral · rabbit89BisacodylC22H19NO43,000 mg/kgoral · rat90MyristicinC11H12O33,000 mg/kgoral · mouse91Zinc sulfateO4SZn2,949 mg/kgoral · rat92Methyl anthranilateC8H9NO22,910 mg/kgoral · rat93Sodium carbonateCNa2O32,800 mg/kgoral · rat94LinaloolC10H18O2,790 mg/kgoral · rat95PiperonalC8H6O32,700 mg/kgoral · rat96BoraxB4Na2O72,660 mg/kgoral · rat97DocusateC20H37NaO7S2,640 mg/kgoral · mouse98Propionic acidC3H6O22,600 mg/kgoral · rat99RetinolC20H30O2,570 mg/kgoral · mouse100EucalyptolC10H18O2,480 mg/kgoral · rat101Succinic acidC4H6O42,260 mg/kgoral · rat102Phenylacetic acidC8H8O22,250 mg/kgoral · rat103Bisphenol AC15H16O22,230 mg/kgoral · rabbit104Sulfuric acidH2O4S2,140 mg/kgoral · rat105AcetophenoneC8H8O2,081 mg/kgoral · rat106Brilliant blue FCFC37H34N2Na2O9S32,000 mg/kgoral · rat107TretinoinC20H28O21,960 mg/kgoral · rat108SafroleC10H10O21,950 mg/kgoral · rat109Glycolic acidC2H4O31,950 mg/kgoral · rat110AcetaminophenC8H9NO21,944 mg/kgoral · rat111Benzoic acidC7H6O21,940 mg/kgoral · mouse112EugenolC10H12O21,930 mg/kgoral · rat113BenzophenoneC13H10O1,900 mg/kgoral · rat114DEETC12H17NO1,892 mg/kgoral · rat115CysteineC3H7NO2S1,890 mg/kgoral · rat116TemazepamC16H13ClN2O21,833 mg/kgoral · rat117QuinineC20H24N2O21,800 mg/kgoral · guinea pig118ProchlorperazineC20H24ClN3S1,800 mg/kgoral · rat119L-DOPAC9H11NO41,780 mg/kgoral · rat120Benzyl benzoateC14H12O21,700 mg/kgoral · rat121Ammonium chlorideClH4N1,650 mg/kgoral · rat122CarvoneC10H14O1,640 mg/kgoral · rat123FuraneolC6H8O31,608 mg/kgoral · mouse124DichloromethaneCH2Cl21,600 mg/kgoral · rat125VanillinC8H8O31,580 mg/kgoral · rat126DiacetylC4H6O21,580 mg/kgoral · rat127GlyphosateC3H8NO5P1,568 mg/kgoral · mouse128Phosphoric acidH3O4P1,530 mg/kgoral · rat129NaltrexoneC20H23NO41,450 mg/kgoral · rat130Caprylic acidC8H16O21,410 mg/kgoral · rat131MaltolC6H6O31,410 mg/kgoral · guinea pig132Raspberry ketoneC10H12O21,320 mg/kgoral · rat133CamphorC10H16O1,310 mg/kgoral · mouse134BenzaldehydeC7H6O1,300 mg/kgoral · rat135Isoamyl alcoholC5H12O1,300 mg/kgoral · rat136Sodium lauryl sulfateC12H25NaO4S1,288 mg/kgoral · rat137Sodium nitrateNNaO31,267 mg/kgoral · rat138NaproxenC14H14O31,234 mg/kgoral · mouse139AlprazolamC17H13ClN41,220 mg/kgoral · rat140MethylglyoxalC3H4O21,165 mg/kgoral · rat141BisoprololC18H31NO41,112 mg/kgoral · rat142ValproateC8H16O21,098 mg/kgoral · mouse143MetforminC4H11N51,000 mg/kgoral · rat144ThymolC10H14O980 mg/kgoral · rat145Salicylic acidC7H6O3891 mg/kgoral · rat146Butylated hydroxytolueneC15H24O890 mg/kgoral · rat147Methyl salicylateC8H8O3887 mg/kgoral · rat148HydroxyzineC21H27ClN2O2840 mg/kgoral · rat149MidazolamC18H13ClFN3825 mg/kgoral · rat150Magnesium oxideMgO810 mg/kgoral · mouse151AmantadineC10H17N800 mg/kgoral · rat152ArsenicAs763 mg/kgoral · rat153MetoclopramideC14H22ClN3O2750 mg/kgoral · rat154Potassium permanganateKMnO4750 mg/kgoral · rat155DiazepamC16H13ClN2O710 mg/kgoral · rat156Formic acidCH2O2700 mg/kgoral · mouse157ZolpidemC19H21N3O695 mg/kgoral · rat158TrazodoneC19H22ClN5O690 mg/kgoral · rat159EthanethiolC2H6S682 mg/kgoral · rat160AcetaldehydeC2H4O661 mg/kgoral · rat161PhenobarbitalC12H12N2O3660 mg/kgoral · rat162LevofloxacinC18H20FN3O4640 mg/kgoral · rat163IbuprofenC13H18O2636 mg/kgoral · rat164ZincZn630 mg/kgoral · rat165Tert-ButylhydroquinoneC10H14O2615 mg/kgoral · rat166NitrofurantoinC8H6N4O5604 mg/kgoral · rat167BupropionC13H18ClNO600 mg/kgoral · rat168EphedrineC10H15NO600 mg/kgoral · rat169PermethrinC21H20Cl2O3600 mg/kgoral · rat170PromethazineC17H20N2S580 mg/kgoral · rabbit171GuaiacolC7H8O2520 mg/kgoral · rat172DiphenhydramineC17H21NO500 mg/kgoral · rat173DiclofenacC14H11Cl2NO2500 mg/kgoral · dog174ParoxetineC19H20FNO3500 mg/kgoral · mouse175TrimethylamineC3H9N500 mg/kgoral · rat176NaphthaleneC10H8490 mg/kgoral · rat177Chloral hydrateC2H3Cl3O2479 mg/kgoral · rat178CodeineC18H21NO3427 mg/kgoral · rat179CyclobenzaprineC20H21N425 mg/kgoral · rat180FlunitrazepamC16H12FN3O3415 mg/kgoral · rat181NortriptylineC19H21N387 mg/kgoral · mouse182Potassium chlorideClK383 mg/kgoral · mouse183HydrocodoneC18H21NO3375 mg/kgoral · rat184AmmoniaH3N350 mg/kgoral · rat185MorphineC17H19NO3335 mg/kgoral · rat186TheophyllineC7H8N4O2332 mg/kgoral · mouse187Iron(II) sulfateFeO4S319 mg/kgoral · rat188LidocaineC14H22N2O317 mg/kgoral · rat189PhenolC6H6O317 mg/kgoral · rat190TapentadolC14H23NO300 mg/kgoral · mouse191TheobromineC7H8N4O2300 mg/kgoral · dog192Copper(II) sulfateCuO4S300 mg/kgoral · rat193ApomorphineC17H17NO2300 mg/kgoral · mouse194CoumarinC9H6O2293 mg/kgoral · rat195Potassium hydroxideHKO273 mg/kgoral · rat196ClozapineC18H19ClN4251 mg/kgoral · rat197TramadolC16H25NO2228 mg/kgoral · rat198CadmiumCd225 mg/kgoral · rat199DextromethorphanC18H25NO201 mg/kgoral · mouse200AspirinC9H8O4200 mg/kgoral · rat201CaffeineC8H10N4O2192 mg/kgoral · rat202MethylphenidateC14H19NO2190 mg/kgoral · mouse203NicotineC10H14N2188 mg/kgoral · rat204PethidineC15H21NO2162 mg/kgoral · rat205QuercetinC15H10O7161 mg/kgoral · rat206DoxepinC19H21NO147 mg/kgoral · rat207ChlorpromazineC17H19ClN2S142 mg/kgoral · rat208AmitriptylineC20H23N140 mg/kgoral · mouse209BuspironeC21H31N5O2136 mg/kgoral · rat210TacrolimusC44H69NO12134 mg/kgoral · rat211HaloperidolC21H23ClFNO2128 mg/kgoral · rat212FurfuralC5H4O2127 mg/kgoral · rat213ClonidineC9H9Cl2N3126 mg/kgoral · rat214SecobarbitalC12H18N2O3125 mg/kgoral · rat215AcrylamideC3H5NO124 mg/kgoral · rat216PentobarbitalC11H18N2O3118 mg/kgoral · rat217Allyl isothiocyanateC4H5NS112 mg/kgoral · rat218SilverAg100 mg/kgoral · mouse219FormaldehydeCH2O100 mg/kgoral · rat220MethadoneC21H27NO86 mg/kgoral · rat221Sodium nitriteNNaO285 mg/kgoral · rat222MeloxicamC14H13N3O4S284 mg/kgoral · rat223TelluriumTe83 mg/kgoral · rat224MethanethiolCH4S61 mg/kgoral · mouse225CapsaicinC18H27NO347.2 mg/kgoral · rat226Sodium fluorideFNa44.3 mg/kgoral · mouse227MethotrexateC20H22N8O543 mg/kgoral · rat228LoperamideC29H33ClN2O240 mg/kgoral · dog229DextroamphetamineC9H13N38 mg/kgoral · rat230AmphetamineC9H13N22 mg/kgoral · mouse231NorepinephrineC8H11NO320 mg/kgoral · mouse232FentanylC22H28N2O18 mg/kgoral · rat233DigoxinC41H64O1417.78 mg/kgoral · mouse234ColchicineC22H25NO65.89 mg/kgoral · mouse← All leaderboards · values carry source citations; the ranking regenerates on every ETL run from source