moleculefinder

Amlodipine

C20H25ClN2O5408.9 g/mol Calculated

A calcium channel blocker sold as Norvasc, used for high blood pressure and angina. Its half-life, 30 to 50 hours, is many times that of nifedipine, the older drug of its class.

Sources and notes
  • The introductionfrom sourceMoleculeFinder curated
  • Formula and weightcomputedPubChem
  • 2D drawingcomputedPubChem structure, drawn by RDKit
  • 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.

Where you encounter it

Dispensed on prescription, not sold on a shelf. Amlodipine on the product labels we hold.

Medicines

NorvascAdded by the makerActive ingredient

Every product and list we hold

Sources and notes
  • The product labels and their strengthsfrom sourceDailyMed (FDA label)Each label lists the molecule as an ingredient, and an active ingredient at the strength shown.
  • How it gets therefrom sourceMoleculeFinder curatedEach mark is set by hand on our lists, never inferred; a label's ingredient is added by the maker. A row with no mark data says Not marked.
  • The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.

Explore its structure

Choose a part to light it up.

A C=O joined through an oxygen to another carbon, the link an acid and an alcohol make when they combine. Water can split it back into the two.

From: standard chemistry.

Sources and notes
  • The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
  • The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.

Compare a related molecule

Amlodipine

Lisinopril

Amlodipine relaxes artery walls by blocking calcium channels, while lisinopril works hormonally by cutting production of angiotensin II.

Amlodipine vs Lisinopril, side by side

Also compared

Sources and notes
  • The sentencefrom sourceMoleculeFinder comparison notesThe pair's answer line.
  • The two drawingscomputedPubChem structures, drawn by RDKitThe two drawings side by side.

Properties and sources

Calculated by PubChem

Molecular formula
C20H25ClN2O5
Molecular weight
408.9 g/mol
XLogP3octanol/water, log units
3
Polar surface areatopological
99.9 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
10
Complexity
647

Reported Hazard label (GHS), ECHA, EU CLP Regulation, Safe Work Australia, HSDB via PubChem

Danger Corrosive pictogram (GHS05), Toxic pictogram (GHS06), Irritant pictogram (GHS07), Health hazard pictogram (GHS08) and Environmental pictogram (GHS09); hazard statements H301, H302, H314, H315, H318, H341, H373, H400, H410, H411

Reported Licence

The US Food and Drug Administration licenses Amlodipine for human use (NDA 019787, authorized July 31, 1992), as Norvasc. Drugs@FDA

Groups it belongs to

Category
Prescription medicine
Family
Blood-pressure medicines
Chemical groups
Amines, Aromatics, Esters, Ethers, Halogenated
Elements
Chlorine, Nitrogen
Hazard classes
Corrosive, Acutely toxic, Irritant, Health hazard, Environmental hazard, GHS Danger
SMILESCCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN

PubChem CID 2162 · Wikidata Q411347 · InChIKey HTIQEAQVCYTUBX-UHFFFAOYSA-N · Data refreshed

How MoleculeFinder sources and labels its data

Questions
What is Amlodipine?
A calcium channel blocker sold as Norvasc, used for high blood pressure and angina. Its half-life, 30 to 50 hours, is many times that of nifedipine, the older drug of its class.
How toxic is Amlodipine?
Its GHS hazard label carries the signal word Danger and the hazard pictograms Corrosive, Toxic, Irritant, Health hazard and Environmental. from source
What kind of molecule is Amlodipine?
Amlodipine has the formula C20H25ClN2O5 and a molecular weight of 408.9 g/mol. MoleculeFinder files it under blood-pressure medicines, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
Who licenses Amlodipine as a medicine?
The US Food and Drug Administration licenses Amlodipine for human use (NDA 019787, authorized July 31, 1992), as Norvasc. from source
Sources and notes
  • Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
  • Hazard labelfrom sourceECHA, EU CLP Regulation, Safe Work Australia, HSDB via PubChemThe label combines these classifications.
  • ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
  • EU CLP Regulationfrom sourceAttributionSource: EUR-Lex, Regulation (EC) No 1272/2008, © European Union.
  • Safe Work Australiafrom sourceAttributionSource: Safe Work Australia, Hazardous Chemical Information System, © Commonwealth of Australia, CC BY 4.0.
  • Licencefrom sourceDrugs@FDARead 2026-10-21.
  • Data refreshedfrom sourceMoleculeFinder2026-11-09

Keep exploring

Compared side by side with amlodipineLisinoprilC21H31N3O5Compared side by side with amlodipineNifedipineC17H18N2O6
Sources and notes
  • Compared side by sidefrom sourceMoleculeFinder comparison notesA molecule we compare it with on its own page.
  • The drawingscomputedPubChem structures, drawn by RDKit