SHEET /vs/lisinopril-vs-losartan · COMPARISON
Lisinopril vs Losartan: what is the difference?
How they differ
Both lower blood pressure by interrupting the same hormone system at different points. Lisinopril is an ACE inhibitor: it blocks the enzyme that converts angiotensin I into angiotensin II, so less of the vessel-tightening hormone is made. Losartan is an angiotensin receptor blocker: the hormone is still made but cannot act on its receptor. That difference explains the best-known side effect split, because ACE also breaks down bradykinin, and the bradykinin that accumulates under lisinopril causes the persistent dry cough that losartan does not. Losartan is much the heavier molecule at 422.9 against 405.5 and carries a tetrazole ring. Both are prescription medicines.
Side by side
| Lisinopril | Losartan | |
|---|---|---|
| Formula | C21H31N3O5 | C22H23ClN6O |
| Molecular weight | 405.5 g/mol | 422.9 g/mol |
| Family | Blood-pressure medicines | Blood-pressure medicines |
| Everyday group | Prescription medicine | Prescription medicine |
| Functional groups | Carboxylic Acids, Amines, Aromatics, Amides | Alcohols, Aromatics, Halogenated |
| GHS signal wordThe supplier-filed hazard label, not a statement about ordinary use. | Danger | Danger |
| CAS number | 76547-98-3 | 114798-26-4 |
| PubChem CID | 5362119 | 3961 |
Common questions
- What is the difference between Lisinopril and Losartan?
- Both lower blood pressure by interrupting the same hormone system at different points. Lisinopril is an ACE inhibitor: it blocks the enzyme that converts angiotensin I into angiotensin II, so less of the vessel-tightening hormone is made. Losartan is an angiotensin receptor blocker: the hormone is still made but cannot act on its receptor.
- Is Lisinopril bigger than Losartan?
- Losartan is the heavier molecule, 422.9 g/mol against 405.5 g/mol for Lisinopril. Lisinopril is C21H31N3O5 and Losartan is C22H23ClN6O.
Read the full records: Lisinopril and Losartan.