Lisinopril vs Losartan: what is the difference?
Lisinopril blocks the enzyme that makes angiotensin II and losartan blocks its receptor, which is why lisinopril can cause a dry cough and losartan does not.
Sources and notes
- The sentence under the titlefrom sourceMoleculeFinder comparison notesThe pair's answer line.
- The two drawingscomputedMoleculeFinder rule (RDKit MCS)Each molecule's own drawing, as its page shows it. The common core, 7 of 30 atoms, is too small to align on.
Side by side
| Lisinopril | Losartan | |
|---|---|---|
| Molecular weightCalculated PubChem | 405.5 g/molC21H31N3O5 | 422.9 g/molC22H23ClN6O |
| Hydrogen-bond donorsCalculated PubChem | 4 | 2 |
| FamilyEditorial MoleculeFinder curated | Blood-pressure medicines | Blood-pressure medicines |
| Everyday groupEditorial MoleculeFinder curated | Prescription medicine | Prescription medicine |
| Chemical groupsCalculated Found by rule (RDKit) | Carboxylic Acids, Amines, Aromatics, Amides | Alcohols, Aromatics, Halogenated |
| Hazard labelReported ECHA via PubChem | Danger | Danger |
| The supplier-filed hazard label's signal word, not a statement about ordinary use. | ||
Sources and notes
- Molecular weightcomputedPubChemComputed from the structure; the formula is under each weight.
- Hydrogen-bond donorscomputedPubChemThe hydrogens on nitrogen or oxygen that each molecule can lend to a hydrogen bond, counted from its structure.
- Familyfrom sourceMoleculeFinder curated
- Everyday groupfrom sourceMoleculeFinder curated
- Chemical groupscomputedFound by rule (RDKit)Each group is found in the structure by a chemical pattern.
- Hazard labelfrom sourceECHA via PubChem
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Identifiersfrom sourcePubChemPubChem CID 5362119 (Lisinopril) and 3961 (Losartan).
In more detail
Both lower blood pressure by interrupting the same hormone system at different points. Lisinopril is an ACE inhibitor: it blocks the enzyme that converts angiotensin I into angiotensin II, so less of the vessel-tightening hormone is made. Losartan is an angiotensin receptor blocker: the hormone is still made but cannot act on its receptor. That difference explains the best-known side effect split, because ACE also breaks down bradykinin, and the bradykinin that accumulates under lisinopril causes the persistent dry cough that losartan does not. Losartan is much the heavier molecule at 422.9 against 405.5 and carries a tetrazole ring. Both are prescription medicines.
Sources and notes
- The paragraphfrom sourceMoleculeFinder comparison notes
Questions
- What is the difference between Lisinopril and Losartan?
- Lisinopril blocks the enzyme that makes angiotensin II and losartan blocks its receptor, which is why lisinopril can cause a dry cough and losartan does not.
- Is Lisinopril bigger than Losartan?
- Losartan is the heavier molecule, 422.9 g/mol against 405.5 g/mol for Lisinopril. Lisinopril is C21H31N3O5 and Losartan is C22H23ClN6O.
Sources and notes
- The answersfrom sourceMoleculeFinderThe first is the pair's answer line; the others are read off the table above.