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SHEET /m/naloxone · PubChem CID 5284596 · CAS 465-65-6 · REV 2026.07

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Naloxone

from source

C19H21NO4 · 327.4 g/mol

N-Allyl-noroxymorphone · n-Allylnoroxymorphone

What is Naloxone?

The opioid antagonist sold as Narcan, which reverses an opioid overdose in minutes and is now sold over the counter in the United States. from source

CategoryOTC medicine
Chemical familyAlcoholsAromaticsKetonesPhenolsEthers
LeaderboardsBiggest

Fig. 1 · 2D structure RDKit

SMILESC=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O

Where you'll find it

Sold over the counter, without a prescription. See the rest of the otc medicine group.

Toxicity & hazards

Toxicity · LD50

90 mg/kg · moderately toxic · LD50 mouse iv from source

4 more reported values
  • 107 mg/kgLD50 · iv · rat
  • 239 mg/kgLD50 · other · rat
  • 286 mg/kgLD50 · other · mouse
  • 500 mg/kgLD50 · other · rat
DangerCorrosiveIrritantH302, H315, H318, H319, H335from source

Keep roaming

Where Naloxone leads

Relatedcomputed
Naltrexone75% similarBoth carry a phenol, an alcohol and an ether group.Oxycodone59% similarBoth carry an alcohol, an ether and a ketone group.Hydromorphone44% similarBoth carry a phenol, an ether and a ketone group.Buprenorphine37% similarBoth carry a phenol, an alcohol and an ether group.

Compare with

Naloxone vs Naltrexone

Sources & methodology

PubChem CID
5284596
Wikidata
Q282902
Structure
PubChem → RDKit
LD50
PubChem
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