SHEET /vs/ropinirole-vs-pramipexole · COMPARISON
Ropinirole vs Pramipexole: what is the difference?
How they differ
Ropinirole and pramipexole are the two dopamine agonists most used for Parkinson's disease and restless legs syndrome, and both act on the D2 and D3 dopamine receptors directly rather than being turned into dopamine like L-DOPA. They are not built alike: ropinirole, C16H24N2O at 260.4, is an indolone, while pramipexole, C10H17N3S at 211.3, carries a sulfur in an aminothiazole ring. Ropinirole is processed by the liver, while pramipexole leaves the body largely unchanged through the kidneys. Both labels list the same well-known side effect, impulse control problems such as compulsive gambling. Both are prescription medicines, sold as Requip and as Mirapex.
Side by side
| Ropinirole | Pramipexole | |
|---|---|---|
| Formula | C16H24N2O | C10H17N3S |
| Molecular weight | 260.37 g/mol | 211.33 g/mol |
| Family | Parkinson's medicines | Parkinson's medicines |
| Everyday group | Prescription medicine | Prescription medicine |
| Functional groups | Aromatics, Amides | Amines |
| GHS signal wordThe supplier-filed hazard label, not a statement about ordinary use. | Warning | Warning |
| LD50A single acute animal measure. It ranks nothing about human safety. | 862 mg/kg (oral, rat) | 210 mg/kg (iv, rat) |
| CAS number | 91374-21-9 | 104632-26-0 |
| PubChem CID | 5095 | 119570 |
Common questions
- What is the difference between Ropinirole and Pramipexole?
- Ropinirole and pramipexole are the two dopamine agonists most used for Parkinson's disease and restless legs syndrome, and both act on the D2 and D3 dopamine receptors directly rather than being turned into dopamine like L-DOPA. They are not built alike: ropinirole, C16H24N2O at 260.4, is an indolone, while pramipexole, C10H17N3S at 211.3, carries a sulfur in an aminothiazole ring. Ropinirole is processed by the liver, while pramipexole leaves the body largely unchanged through the kidneys.
- Is Ropinirole bigger than Pramipexole?
- Ropinirole is the heavier molecule, 260.37 g/mol against 211.33 g/mol for Pramipexole. Ropinirole is C16H24N2O and Pramipexole is C10H17N3S.
Read the full records: Ropinirole and Pramipexole.