Losartan vs Valsartan: what is the difference?
Both block the angiotensin II receptor, but losartan depends partly on the liver making a more active metabolite, and valsartan is active as given.
Sources and notes
- The sentence under the titlefrom sourceMoleculeFinder comparison notesThe pair's answer line.
- The two drawingscomputedMoleculeFinder rule (RDKit MCS)Drawn the same way round on the skeleton they share. Aligned; 26 atoms differ, too many to mark as one group.
- Structural similaritycomputedRDKit Morgan/Tanimoto0.44 of 1, a Morgan fingerprint Tanimoto coefficient. It measures shape, not effect.
Side by side
| Losartan | Valsartan | |
|---|---|---|
| Molecular weightCalculated PubChem | 422.9 g/molC22H23ClN6O | 435.5 g/molC24H29N5O3 |
| Hydrogen-bond donorsCalculated PubChem | 2 | 2 |
| FamilyEditorial MoleculeFinder curated | Blood-pressure medicines | Blood-pressure medicines |
| Everyday groupEditorial MoleculeFinder curated | Prescription medicine | Prescription medicine |
| Chemical groupsCalculated Found by rule (RDKit) | Alcohols, Aromatics, Halogenated | Carboxylic Acids, Aromatics, Amides |
| Hazard labelReported ECHA via PubChem | Danger | Danger |
| The supplier-filed hazard label's signal word, not a statement about ordinary use. | ||
Sources and notes
- Molecular weightcomputedPubChemComputed from the structure; the formula is under each weight.
- Hydrogen-bond donorscomputedPubChemThe hydrogens on nitrogen or oxygen that each molecule can lend to a hydrogen bond, counted from its structure.
- Familyfrom sourceMoleculeFinder curated
- Everyday groupfrom sourceMoleculeFinder curated
- Chemical groupscomputedFound by rule (RDKit)Each group is found in the structure by a chemical pattern.
- Hazard labelfrom sourceECHA via PubChem
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Identifiersfrom sourcePubChemPubChem CID 3961 (Losartan) and 60846 (Valsartan).
In more detail
Both keep angiotensin II from acting on its receptor, and they differ mainly in pharmacokinetics. Losartan is a prodrug in part: the liver converts some of it into a metabolite that is considerably more active than the parent, so its effect depends on that conversion. Valsartan is active as given. Losartan also has a mild uric-acid lowering effect that the rest of the class does not share, which is a genuinely distinctive property. Valsartan is the heavier at 435.5 against 422.9 and carries a carboxylic acid where losartan carries an alcohol. Both are prescription medicines and both belong to a class that came out of a large recall over nitrosamine contamination in the late 2010s.
Sources and notes
- The paragraphfrom sourceMoleculeFinder comparison notes
Questions
- What is the difference between Losartan and Valsartan?
- Both block the angiotensin II receptor, but losartan depends partly on the liver making a more active metabolite, and valsartan is active as given.
- Is Losartan bigger than Valsartan?
- Valsartan is the heavier molecule, 435.5 g/mol against 422.9 g/mol for Losartan. Losartan is C22H23ClN6O and Valsartan is C24H29N5O3.
Sources and notes
- The answersfrom sourceMoleculeFinderThe first is the pair's answer line; the others are read off the table above.