Hydrochlorothiazide vs Furosemide: what is the difference?
Furosemide is a strong loop diuretic acting in the loop of Henle, while hydrochlorothiazide acts further along the kidney tubule and is gentler.
Sources and notes
- The sentence under the titlefrom sourceMoleculeFinder comparison notesThe pair's answer line.
- The two drawingscomputedMoleculeFinder rule (RDKit MCS)Drawn the same way round on the skeleton they share. Aligned; 16 atoms differ, too many to mark as one group.
Side by side
| Hydrochlorothiazide | Furosemide | |
|---|---|---|
| Molecular weightCalculated PubChem | 297.7 g/molC7H8ClN3O4S2 | 330.74 g/molC12H11ClN2O5S |
| Hydrogen-bond donorsCalculated PubChem | 3 | 3 |
| FamilyEditorial MoleculeFinder curated | Blood-pressure medicines | Blood-pressure medicines |
| Everyday groupEditorial MoleculeFinder curated | Prescription medicine | Prescription medicine |
| Chemical groupsCalculated Found by rule (RDKit) | Amines, Aromatics, Halogenated | Carboxylic Acids, Amines, Aromatics, Halogenated |
| Hazard labelReported ECHA via PubChem; ECHA, HSDB via PubChem | Danger | Danger |
| The supplier-filed hazard label's signal word, not a statement about ordinary use. | ||
| LD50Measured HSDB via PubChem | 250 mg/kgpure hydrochlorothiazide, dog, intravenous | 800 mg/kgpure furosemide, rat, intravenous |
| A single acute animal measure, here in two different species. It ranks nothing about human safety. | ||
Sources and notes
- Molecular weightcomputedPubChemComputed from the structure; the formula is under each weight.
- Hydrogen-bond donorscomputedPubChemThe hydrogens on nitrogen or oxygen that each molecule can lend to a hydrogen bond, counted from its structure.
- Familyfrom sourceMoleculeFinder curated
- Everyday groupfrom sourceMoleculeFinder curated
- Chemical groupscomputedFound by rule (RDKit)Each group is found in the structure by a chemical pattern.
- Hazard labelfrom sourceECHA via PubChem; ECHA, HSDB via PubChem
- LD50from sourceHSDB via PubChem
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Identifiersfrom sourcePubChemPubChem CID 3639 (Hydrochlorothiazide) and 3440 (Furosemide).
In more detail
Both are diuretics, and where each acts decides how strong it is. Furosemide is a loop diuretic, blocking sodium reabsorption in the thick ascending limb, which takes back about a quarter of the filtered sodium, so it produces a large and fast urine output and is used for fluid overload in heart failure. Hydrochlorothiazide acts further along in the distal tubule, where much less sodium is available to block, so it is gentler and is used for ongoing blood pressure control. They also differ on calcium: thiazides retain it and loop diuretics lose it, which matters for bone and for kidney stones. Furosemide is the heavier at 330.7 against 297.7 and both carry a sulfonamide group.
Sources and notes
- The paragraphfrom sourceMoleculeFinder comparison notes
Questions
- What is the difference between Hydrochlorothiazide and Furosemide?
- Furosemide is a strong loop diuretic acting in the loop of Henle, while hydrochlorothiazide acts further along the kidney tubule and is gentler.
- Is Hydrochlorothiazide bigger than Furosemide?
- Furosemide is the heavier molecule, 330.74 g/mol against 297.7 g/mol for Hydrochlorothiazide. Hydrochlorothiazide is C7H8ClN3O4S2 and Furosemide is C12H11ClN2O5S.
Sources and notes
- The answersfrom sourceMoleculeFinderThe first is the pair's answer line; the others are read off the table above.