Hydrochlorothiazide
Also called Chlorosulthiadil, Esidrix, HCTZ and Hidrotiazida.
A thiazide diuretic, in use since 1959: it makes the kidney pass more salt, and water follows. It is often combined with another blood pressure medicine in one tablet.
Sources and notes
- The introductionfrom sourceMoleculeFinder curated
- Other namesfrom sourcePubChem / Wikidata
- Formula and weightcomputedPubChem
- 2D drawingcomputedPubChem structure, drawn by RDKit
- 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.
Where you encounter it
Dispensed on prescription, not sold on a shelf.
Sources and notes
- The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.
Explore its structure
Choose a part to light it up.
A sulfur carrying two oxygens and a nitrogen, written SO2N. It is a polar, sturdy group, the one the sulfa drugs are named for.
From: standard chemistry.
Fluorine, chlorine, bromine or iodine bonded to carbon. Each pulls electrons toward itself, and each is larger than the hydrogen the carbon would otherwise carry.
From: standard chemistry.
Rings joined where they share atoms, or a single ring standing alone. Atoms in a ring are held in place, so this part keeps its shape while chains around it can bend.
From: standard chemistry.
Sources and notes
- The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
- The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.
Compare a related molecule
Hydrochlorothiazide
Furosemide
Furosemide is a strong loop diuretic acting in the loop of Henle, while hydrochlorothiazide acts further along the kidney tubule and is gentler.
Hydrochlorothiazide vs Furosemide, side by sideSources and notes
- The sentencefrom sourceMoleculeFinder comparison notesThe pair's answer line.
- The two drawingscomputedPubChem structures, drawn by RDKitThe two drawings side by side.
Properties and sources
Calculated by PubChem
- Molecular formula
- C7H8ClN3O4S2
- Molecular weight
- 297.7 g/mol
- XLogP3octanol/water, log units
- −0.1
- Polar surface areatopological
- 135 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Rotatable bonds
- 1
- Complexity
- 494
Measured LD50, HSDB via PubChem
250 mg/kg pure hydrochlorothiazide, dog, intravenous
An LD50 is an animal study measurement, not a dose for a person.
Reported Hazard label (GHS), ECHA via PubChem
Danger Irritant pictogram (GHS07) and Health hazard pictogram (GHS08); hazard statements H302, H317, H334, H372
Reported Licence
The US Food and Drug Administration licenses Hydrochlorothiazide for human use (NDA 020504, authorized December 27, 1996), as Microzide. Drugs@FDA
Groups it belongs to
- Category
- Prescription medicine
- Family
- Blood-pressure medicines
- Chemical groups
- Amines, Aromatics, Halogenated
- Hazard classes
- Irritant, Health hazard, GHS Danger
C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)ClPubChem CID 3639 · Wikidata Q423930 · InChIKey JZUFKLXOESDKRF-UHFFFAOYSA-N · Data refreshed
Questions
- What is Hydrochlorothiazide?
- A thiazide diuretic, in use since 1959: it makes the kidney pass more salt, and water follows. It is often combined with another blood pressure medicine in one tablet.
- How toxic is Hydrochlorothiazide?
- The reported LD50 of Hydrochlorothiazide is 250 mg/kg (dog, iv). An LD50 is an animal study measurement, not a dose for a person. Its GHS hazard label carries the signal word Danger and the hazard pictograms Irritant and Health hazard. from sourcefrom source
- What kind of molecule is Hydrochlorothiazide?
- Hydrochlorothiazide has the formula C7H8ClN3O4S2 and a molecular weight of 297.7 g/mol. MoleculeFinder files it under blood-pressure medicines, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
- Who licenses Hydrochlorothiazide as a medicine?
- The US Food and Drug Administration licenses Hydrochlorothiazide for human use (NDA 020504, authorized December 27, 1996), as Microzide. from source
Sources and notes
- Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
- LD50from sourceHSDB via PubChemOther values the sources report: rabbit, intravenous, 461 mg/kg; mouse, another route, 578 mg/kg; mouse, another route, 1,470 mg/kg. The page shows the one LD50 the site uses everywhere.
- Hazard labelfrom sourceECHA via PubChemThe label combines these classifications.
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Licencefrom sourceDrugs@FDARead 2026-10-21.
- Data refreshedfrom sourceMoleculeFinder2026-11-09
Keep exploring
Sources and notes
- Compared side by sidefrom sourceMoleculeFinder comparison notesA molecule we compare it with on its own page.
- The drawingscomputedPubChem structures, drawn by RDKit