Tadalafil
Also called Cialis.
The PDE5 inhibitor sold as Cialis, used for erectile dysfunction, enlarged prostate and pulmonary hypertension. It lasts far longer than sildenafil.
Sources and notes
- The introductionfrom sourceMoleculeFinder curated
- Other namesfrom sourcePubChem / Wikidata
- Formula and weightcomputedPubChem
- 2D drawingcomputedPubChem structure, drawn by RDKit
- 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.
Where you encounter it
Dispensed on prescription, not sold on a shelf. Tadalafil on the product labels we hold.
Medicines
Every product and list we hold
Sources and notes
- The product labels and their strengthsfrom sourceDailyMed (FDA label)Each label lists the molecule as an ingredient, and an active ingredient at the strength shown.
- How it gets therefrom sourceMoleculeFinder curatedEach mark is set by hand on our lists, never inferred; a label's ingredient is added by the maker. A row with no mark data says Not marked.
- The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.
Explore its structure
Choose a part to light it up.
A C=O bonded to a nitrogen, the same link that joins amino acids in a protein. It is sturdy, and its nitrogen is not a base the way an amine's is.
From: standard chemistry.
One carbon bonded to two oxygens, each joined in turn to another carbon. It is the kind of link that joins sugars together: it stands up to bases, and acid splits it.
From: standard chemistry.
Rings joined where they share atoms, or a single ring standing alone. Atoms in a ring are held in place, so this part keeps its shape while chains around it can bend.
From: standard chemistry.
Sources and notes
- The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
- The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.
Compare a related molecule
Sildenafil
Tadalafil
Sildenafil and tadalafil are both PDE5 inhibitors, but sildenafil acts for about four to six hours while tadalafil's effect can span a day and a half.
Sildenafil vs Tadalafil, side by sideSources and notes
- The sentencefrom sourceMoleculeFinder comparison notesThe pair's answer line.
- The two drawingscomputedPubChem structures, drawn by RDKitThe two drawings side by side.
Properties and sources
Calculated by PubChem
- Molecular formula
- C22H19N3O4
- Molecular weight
- 389.4 g/mol
- XLogP3octanol/water, log units
- 2.3
- Polar surface areatopological
- 74.9 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Rotatable bonds
- 1
- Complexity
- 702
Reported Hazard label (GHS), ECHA via PubChem
Warning Irritant pictogram (GHS07); hazard statements H302, H312, H315, H319, H332, H335
Reported Licence
The US Food and Drug Administration licenses Tadalafil for human use (NDA 021368, authorized November 21, 2003). Drugs@FDA
Groups it belongs to
- Category
- Prescription medicine
- Elements
- Nitrogen
- Hazard classes
- Irritant, GHS Warning
CN1CC(=O)N2[C@@H](C1=O)CC3=C([C@H]2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36PubChem CID 110635 · Wikidata Q424156 · InChIKey WOXKDUGGOYFFRN-IIBYNOLFSA-N · Data refreshed
Questions
- What is Tadalafil?
- The PDE5 inhibitor sold as Cialis, used for erectile dysfunction, enlarged prostate and pulmonary hypertension. It lasts far longer than sildenafil.
- How toxic is Tadalafil?
- Its GHS hazard label carries the signal word Warning and the hazard pictogram Irritant. from source
- What kind of molecule is Tadalafil?
- Tadalafil has the formula C22H19N3O4 and a molecular weight of 389.4 g/mol. MoleculeFinder files it under PDE5 inhibitor, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
- Who licenses Tadalafil as a medicine?
- The US Food and Drug Administration licenses Tadalafil for human use (NDA 021368, authorized November 21, 2003). from source
Sources and notes
- Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
- Hazard labelfrom sourceECHA via PubChemThe label combines these classifications.
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Licencefrom sourceDrugs@FDARead 2026-10-21.
- Data refreshedfrom sourceMoleculeFinder2026-11-09
Keep exploring
Sources and notes
- Compared side by sidefrom sourceMoleculeFinder comparison notesA molecule we compare it with on its own page.
- The drawingscomputedPubChem structures, drawn by RDKit