moleculefinder

Sildenafil

C22H30N6O4S474.6 g/mol Calculated

Also called Aphrodil, Nipatra, Patrex and Vizarsin.

The PDE5 inhibitor sold as Viagra, developed for angina and repurposed for erectile dysfunction and pulmonary hypertension.

Sources and notes
  • The introductionfrom sourceMoleculeFinder curated
  • Other namesfrom sourcePubChem / Wikidata
  • Formula and weightcomputedPubChem
  • 2D drawingcomputedPubChem structure, drawn by RDKit
  • 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.

Where you encounter it

Dispensed on prescription, not sold on a shelf. Sildenafil on the product labels we hold.

Medicines

ViagraAdded by the makerActive ingredient

Every product and list we hold

Sources and notes
  • The product labels and their strengthsfrom sourceDailyMed (FDA label)Each label lists the molecule as an ingredient, and an active ingredient at the strength shown.
  • How it gets therefrom sourceMoleculeFinder curatedEach mark is set by hand on our lists, never inferred; a label's ingredient is added by the maker. A row with no mark data says Not marked.
  • The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.

Explore its structure

Choose a part to light it up.

A sulfur carrying two oxygens and a nitrogen, written SO2N. It is a polar, sturdy group, the one the sulfa drugs are named for.

From: standard chemistry.

Sources and notes
  • The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
  • The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.

Compare a related molecule

Sildenafil

Tadalafil

Sildenafil and tadalafil are both PDE5 inhibitors, but sildenafil acts for about four to six hours while tadalafil's effect can span a day and a half.

Sildenafil vs Tadalafil, side by side
Sources and notes
  • The sentencefrom sourceMoleculeFinder comparison notesThe pair's answer line.
  • The two drawingscomputedPubChem structures, drawn by RDKitThe two drawings side by side.

Properties and sources

Calculated by PubChem

Molecular formula
C22H30N6O4S
Molecular weight
474.6 g/mol
XLogP3octanol/water, log units
1.5
Polar surface areatopological
118 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
7
Complexity
838

Reported Hazard label (GHS), ECHA, HSDB via PubChem

Warning Irritant pictogram (GHS07); hazard statements H302, H315, H319, H335, H412

Reported Licence

The US Food and Drug Administration licenses Sildenafil for human use (NDA 020895, authorized March 27, 1998), as Viagra. Drugs@FDA

Groups it belongs to

Category
Prescription medicine
Chemical groups
Aromatics, Ethers
Elements
Nitrogen, Sulfur
Hazard classes
Irritant, GHS Warning
SMILESCCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C

PubChem CID 135398744 · Wikidata Q191521 · InChIKey BNRNXUUZRGQAQC-UHFFFAOYSA-N · Data refreshed

How MoleculeFinder sources and labels its data

Questions
What is Sildenafil?
The PDE5 inhibitor sold as Viagra, developed for angina and repurposed for erectile dysfunction and pulmonary hypertension.
How toxic is Sildenafil?
Its GHS hazard label carries the signal word Warning and the hazard pictogram Irritant. from source
What kind of molecule is Sildenafil?
Sildenafil has the formula C22H30N6O4S and a molecular weight of 474.6 g/mol. MoleculeFinder files it under PDE5 inhibitor, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
Who licenses Sildenafil as a medicine?
The US Food and Drug Administration licenses Sildenafil for human use (NDA 020895, authorized March 27, 1998), as Viagra. from source
Sources and notes
  • Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
  • Hazard labelfrom sourceECHA, HSDB via PubChemThe label combines these classifications.
  • ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
  • Licencefrom sourceDrugs@FDARead 2026-10-21.
  • Data refreshedfrom sourceMoleculeFinder2026-11-09

Keep exploring

Compared side by side with sildenafilTadalafilC22H19N3O4
Sources and notes
  • Compared side by sidefrom sourceMoleculeFinder comparison notesA molecule we compare it with on its own page.
  • The drawingscomputedPubChem structures, drawn by RDKit