Duloxetine
Also called Xeristar and Yentreve.
An SNRI antidepressant sold as Cymbalta, used for depression, anxiety, nerve pain and fibromyalgia. Duloxetine (C18H19NOS, 297 g/mol) is a serotonin-norepinephrine reuptake inhibitor dispensed on prescription.
Sources and notes
- The introductionfrom sourceMoleculeFinder curated
- Other namesfrom sourcePubChem / Wikidata
- Formula and weightcomputedPubChem
- 2D drawingcomputedPubChem structure, drawn by RDKit
- 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.
Where you encounter it
Dispensed on prescription, not sold on a shelf.
Sources and notes
- The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.
Explore its structure
Choose a part to light it up.
A nitrogen carrying one or two hydrogens. Its spare pair of electrons can pick up a hydrogen ion, so an amine is a base.
From: standard chemistry.
An oxygen bridging two carbons, written C-O-C. It accepts hydrogen bonds but has no hydrogen to give, and it is slow to react.
From: standard chemistry.
Rings joined where they share atoms, or a single ring standing alone. Atoms in a ring are held in place, so this part keeps its shape while chains around it can bend.
From: standard chemistry.
Sources and notes
- The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
- The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.
Compare a related molecule
Duloxetine
Venlafaxine
Duloxetine and venlafaxine are both SNRIs, but venlafaxine acts mostly on serotonin at lower amounts while duloxetine hits both transmitters from the start.
Duloxetine vs Venlafaxine, side by sideSources and notes
- The sentencefrom sourceMoleculeFinder comparison notesThe pair's answer line.
- The two drawingscomputedPubChem structures, drawn by RDKitThe two drawings side by side.
Properties and sources
Calculated by PubChem
- Molecular formula
- C18H19NOS
- Molecular weight
- 297.4 g/mol
- XLogP3octanol/water, log units
- 4.3
- Polar surface areatopological
- 49.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Rotatable bonds
- 6
- Complexity
- 312
Reported Hazard label (GHS), ECHA, HSDB via PubChem
Danger Flammable pictogram (GHS02), Toxic pictogram (GHS06) and Health hazard pictogram (GHS08); hazard statements H225, H301, H311, H331, H351, H361, H370
Reported Licence
The US Food and Drug Administration licenses Duloxetine for human use (NDA 021733, authorized September 3, 2004), as Cymbalta. Drugs@FDA
Groups it belongs to
- Category
- Prescription medicine
- Family
- SNRIs
- Hazard classes
- Flammable, Acutely toxic, Health hazard, GHS Danger
CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32PubChem CID 60835 · Wikidata Q411932 · InChIKey ZEUITGRIYCTCEM-KRWDZBQOSA-N · Data refreshed
Questions
- What is Duloxetine?
- An SNRI antidepressant sold as Cymbalta, used for depression, anxiety, nerve pain and fibromyalgia. Duloxetine (C18H19NOS, 297 g/mol) is a serotonin-norepinephrine reuptake inhibitor dispensed on prescription.
- How toxic is Duloxetine?
- Its GHS hazard label carries the signal word Danger and the hazard pictograms Flammable, Toxic and Health hazard. from source
- What kind of molecule is Duloxetine?
- Duloxetine has the formula C18H19NOS and a molecular weight of 297.4 g/mol. MoleculeFinder files it under SNRIs, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
- Who licenses Duloxetine as a medicine?
- The US Food and Drug Administration licenses Duloxetine for human use (NDA 021733, authorized September 3, 2004), as Cymbalta. from source
Sources and notes
- Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
- Hazard labelfrom sourceECHA, HSDB via PubChemThe label combines these classifications.
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Licencefrom sourceDrugs@FDARead 2026-10-21.
- Data refreshedfrom sourceMoleculeFinder2026-11-09
Keep exploring
Sources and notes
- Compared side by sidefrom sourceMoleculeFinder comparison notesA molecule we compare it with on its own page.
- Similar in shapecomputedRDKit Morgan/TanimotoNeighbours by structural fingerprint; the sentence names the chemical groups the two share.
- The drawingscomputedPubChem structures, drawn by RDKit