Adapalene

from source

C28H28O3 · 412.5 g/mol

Adaferin · Differine · Differin

What is Adapalene?

An acne gel sold as Differin, the first retinoid sold without a prescription in the United States, in 2016. It is a lab-designed cousin of vitamin A acid. from source

CategoryOTC medicine

Chemical familyCarboxylic Acids Aromatics Ethers

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Fig. 1 · 2D structure RDKit

SMILESCOC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5

Where you'll find it

Sold over the counter, without a prescription. See the rest of the otc medicine group.

Toxicity & hazards

WarningIrritantHealth hazardH302, H315, H317, H319, H335, H361from source

Compare with

Adapalene vs Tretinoin

Sources & methodology

PubChem CID: 60164
Wikidata: Q352348
Structure: PubChem → RDKit
Data refreshed: October 19, 2026

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