Temazepam vs Zopiclone: what is the difference?
Temazepam is a benzodiazepine that also eases anxiety and relaxes muscle; zopiclone is a z-drug that targets sleep more narrowly and leaves a metallic taste.
Sources and notes
- The sentence under the titlefrom sourceMoleculeFinder comparison notesThe pair's answer line.
- The two drawingscomputedMoleculeFinder rule (RDKit MCS)Each molecule's own drawing, as its page shows it. The common core, 2 of 27 atoms, is too small to align on.
Side by side
| Temazepam | Zopiclone | |
|---|---|---|
| Molecular weightCalculated PubChem | 300.74 g/molC16H13ClN2O2 | 388.8 g/molC17H17ClN6O3 |
| Hydrogen-bond donorsCalculated PubChem | 1 | 0 |
| FamilyEditorial MoleculeFinder curated | Benzodiazepines | Sleep medicines |
| Everyday groupEditorial MoleculeFinder curated | Prescription medicine | Prescription medicine |
| Chemical groupsCalculated Found by rule (RDKit) | Alcohols, Aromatics, Amides, Halogenated | Esters, Amides, Halogenated |
| Hazard labelReported ECHA via PubChem | Warning | Warning |
| The supplier-filed hazard label's signal word, not a statement about ordinary use. | ||
Sources and notes
- Molecular weightcomputedPubChemComputed from the structure; the formula is under each weight.
- Hydrogen-bond donorscomputedPubChemThe hydrogens on nitrogen or oxygen that each molecule can lend to a hydrogen bond, counted from its structure.
- Familyfrom sourceMoleculeFinder curated
- Everyday groupfrom sourceMoleculeFinder curated
- Chemical groupscomputedFound by rule (RDKit)Each group is found in the structure by a chemical pattern.
- Hazard labelfrom sourceECHA via PubChem
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Identifiersfrom sourcePubChemPubChem CID 5391 (Temazepam) and 5735 (Zopiclone).
In more detail
Both are prescription sleep medicines that act on the GABA-A receptor, and neither carries an LD50 in this catalog. Temazepam is a true benzodiazepine, C16H13ClN2O2 at 300.74, sold as Restoril in the United States, and it binds across the receptor's subtypes, so it brings the anxiety-easing and muscle-relaxing effects of the class along with the sedation. Zopiclone, C17H17ClN6O3 at 388.8 and sold as Zimovane in the UK, is a cyclopyrrolone, one of the z-drugs, which favour the subtype behind sedation and do less for anxiety. Zopiclone is cleared faster, with a half-life near 5 hours against temazepam's 8 to 10, and it is secreted into saliva, which is the bitter metallic taste people report the next morning. Zopiclone has never been approved in the United States, where its single active form, eszopiclone, is sold instead.
Sources and notes
- The paragraphfrom sourceMoleculeFinder comparison notes
Questions
- What is the difference between Temazepam and Zopiclone?
- Temazepam is a benzodiazepine that also eases anxiety and relaxes muscle; zopiclone is a z-drug that targets sleep more narrowly and leaves a metallic taste.
- Is Temazepam bigger than Zopiclone?
- Zopiclone is the heavier molecule, 388.8 g/mol against 300.74 g/mol for Temazepam. Temazepam is C16H13ClN2O2 and Zopiclone is C17H17ClN6O3.
Sources and notes
- The answersfrom sourceMoleculeFinderThe first is the pair's answer line; the others are read off the table above.