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Sucralose vs Stevioside: what is the difference?

Sucralose is made in a factory from sugar and stevioside is extracted from the stevia leaf, and sucralose is the sweeter of the two.

SucraloseC12H19Cl3O8
SteviosideC38H60O18
Sources and notes
  • The sentence under the titlefrom sourceMoleculeFinder comparison notesThe pair's answer line.
  • The two drawingscomputedMoleculeFinder rule (RDKit MCS)Each molecule's own drawing, as its page shows it. The common core, 12 of 56 atoms, is too small to align on.

Side by side

 SucraloseStevioside
Molecular weightCalculated PubChem397.6 g/molC12H19Cl3O8804.9 g/molC38H60O18
Hydrogen-bond donorsCalculated PubChem511
SweetnessMeasured FDA; MeSH600× sugar300× sugar
Against table sugar, which is 1.
Where each turns upEditorial MoleculeFinder food and product lists
FamilyEditorial MoleculeFinder curatedSweetenerGlycosides
Everyday groupEditorial MoleculeFinder curatedSweetenerSweetener
Chemical groupsCalculated Found by rule (RDKit)Alcohols, Ethers, HalogenatedAlcohols, Esters, Ethers
Hazard labelReported ECHA via PubChemNot recordedWarning
The supplier-filed hazard label's signal word, not a statement about ordinary use.
Sources and notes
  • Molecular weightcomputedPubChemComputed from the structure; the formula is under each weight.
  • Hydrogen-bond donorscomputedPubChemThe hydrogens on nitrogen or oxygen that each molecule can lend to a hydrogen bond, counted from its structure.
  • Sweetnessfrom sourceFDA; MeSH
  • Where each turns upfrom sourceMoleculeFinder food and product listsEach amount is an editorial figure from our lists, not a measurement of any one product. Each mark is set by hand on the list, never inferred.
  • Familyfrom sourceMoleculeFinder curated
  • Everyday groupfrom sourceMoleculeFinder curated
  • Chemical groupscomputedFound by rule (RDKit)Each group is found in the structure by a chemical pattern.
  • Hazard labelfrom sourceECHA via PubChem
  • ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
  • Identifiersfrom sourcePubChemPubChem CID 71485 (Sucralose) and 442089 (Stevioside).

In more detail

Where each comes from is half the story; the molecules differ just as much. Sucralose is sucrose with three chlorines substituted in, indigestible and about 600 times as sweet as sugar. Stevioside is a steviol glycoside from the Stevia rebaudiana leaf, a much larger molecule at 804.9 against 397.6, around 300 times as sweet, and it carries a liquorice bitterness in the aftertaste that sucralose does not have. Stevia sweeteners are often purified away from stevioside toward rebaudioside A precisely to lose that bitterness. Both pass through largely unmetabolised, which is why both contribute essentially no calories.

Sources and notes
  • The paragraphfrom sourceMoleculeFinder comparison notes

Questions

What is the difference between Sucralose and Stevioside?
Sucralose is made in a factory from sugar and stevioside is extracted from the stevia leaf, and sucralose is the sweeter of the two.
Is Sucralose bigger than Stevioside?
Stevioside is the heavier molecule, 804.9 g/mol against 397.6 g/mol for Sucralose. Sucralose is C12H19Cl3O8 and Stevioside is C38H60O18.
Is Sucralose sweeter than Stevioside?
Sucralose is the sweeter of the two, about 600 times as sweet as table sugar against about 300 times for Stevioside. Sweetness here is measured against sucrose, which is defined as 1.
Sources and notes
  • The answersfrom sourceMoleculeFinderThe first is the pair's answer line; the others are read off the table above.

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