Quetiapine vs Olanzapine: what is the difference?
Quetiapine binds the dopamine D2 receptor loosely and is heavily sedating, while olanzapine binds more firmly and is more strongly tied to weight gain.
Sources and notes
- The sentence under the titlefrom sourceMoleculeFinder comparison notesThe pair's answer line.
- The two drawingscomputedMoleculeFinder rule (RDKit MCS)Each molecule's own drawing, as its page shows it. The common core, 8 of 27 atoms, is too small to align on.
Side by side
| Quetiapine | Olanzapine | |
|---|---|---|
| Molecular weightCalculated PubChem | 383.5 g/molC21H25N3O2S | 312.4 g/molC17H20N4S |
| Hydrogen-bond donorsCalculated PubChem | 1 | 1 |
| FamilyEditorial MoleculeFinder curated | Antipsychotics | Antipsychotics |
| Everyday groupEditorial MoleculeFinder curated | Prescription medicine | Prescription medicine |
| Chemical groupsCalculated Found by rule (RDKit) | Alcohols, Aromatics, Ethers | Amines, Aromatics |
| Hazard labelReported ECHA, HSDB via PubChem; ECHA via PubChem | Danger | Danger |
| The supplier-filed hazard label's signal word, not a statement about ordinary use. | ||
Sources and notes
- Molecular weightcomputedPubChemComputed from the structure; the formula is under each weight.
- Hydrogen-bond donorscomputedPubChemThe hydrogens on nitrogen or oxygen that each molecule can lend to a hydrogen bond, counted from its structure.
- Familyfrom sourceMoleculeFinder curated
- Everyday groupfrom sourceMoleculeFinder curated
- Chemical groupscomputedFound by rule (RDKit)Each group is found in the structure by a chemical pattern.
- Hazard labelfrom sourceECHA, HSDB via PubChem; ECHA via PubChem
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Identifiersfrom sourcePubChemPubChem CID 5002 (Quetiapine) and 135398745 (Olanzapine).
In more detail
Both are atypical antipsychotics that block dopamine D2 and serotonin 5-HT2A receptors. Quetiapine binds D2 loosely and comes off quickly, which is why it causes relatively few movement side effects and why it is heavily sedating at lower amounts through its antihistamine activity. Olanzapine binds more firmly and is the more reliably antipsychotic of the two, at the cost of a stronger association with weight gain and metabolic change. Both carry sedation, and both are prescription only. Quetiapine is a dibenzothiazepine at 383.5 and olanzapine a thienobenzodiazepine at 312.4, so they are structural cousins rather than the same skeleton.
Sources and notes
- The paragraphfrom sourceMoleculeFinder comparison notes
Questions
- What is the difference between Quetiapine and Olanzapine?
- Quetiapine binds the dopamine D2 receptor loosely and is heavily sedating, while olanzapine binds more firmly and is more strongly tied to weight gain.
- Is Quetiapine bigger than Olanzapine?
- Quetiapine is the heavier molecule, 383.5 g/mol against 312.4 g/mol for Olanzapine. Quetiapine is C21H25N3O2S and Olanzapine is C17H20N4S.
Sources and notes
- The answersfrom sourceMoleculeFinderThe first is the pair's answer line; the others are read off the table above.