Estradiol vs Testosterone: what is the difference?
Estradiol is made from testosterone by the enzyme aromatase; testosterone predominates in men and estradiol in women, and everyone makes both.
Sources and notes
- The sentence under the titlefrom sourceMoleculeFinder comparison notesThe pair's answer line.
- The two drawingscomputedMoleculeFinder rule (RDKit MCS)Drawn the same way round on the skeleton they share. Aligned; 11 atoms differ, too many to mark as one group.
- Structural similaritycomputedRDKit Morgan/Tanimoto0.42 of 1, a Morgan fingerprint Tanimoto coefficient. It measures shape, not effect.
Side by side
| Estradiol | Testosterone | |
|---|---|---|
| Molecular weightCalculated PubChem | 272.4 g/molC18H24O2 | 288.4 g/molC19H28O2 |
| Hydrogen-bond donorsCalculated PubChem | 2 | 1 |
| FamilyEditorial MoleculeFinder curated | Steroid hormones | Steroid hormones |
| Everyday groupEditorial MoleculeFinder curated | Body | Body |
| Chemical groupsCalculated Found by rule (RDKit) | Alcohols, Aromatics, Phenols | Alcohols, Ketones |
| Hazard labelReported ECHA via PubChem; ECHA, HSDB via PubChem | Danger | Danger |
| The supplier-filed hazard label's signal word, not a statement about ordinary use. | ||
Sources and notes
- Molecular weightcomputedPubChemComputed from the structure; the formula is under each weight.
- Hydrogen-bond donorscomputedPubChemThe hydrogens on nitrogen or oxygen that each molecule can lend to a hydrogen bond, counted from its structure.
- Familyfrom sourceMoleculeFinder curated
- Everyday groupfrom sourceMoleculeFinder curated
- Chemical groupscomputedFound by rule (RDKit)Each group is found in the structure by a chemical pattern.
- Hazard labelfrom sourceECHA via PubChem; ECHA, HSDB via PubChem
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Identifiersfrom sourcePubChemPubChem CID 5757 (Estradiol) and 6013 (Testosterone).
In more detail
These are the two headline sex hormones. The enzyme aromatase converts testosterone into estradiol by aromatising the first ring, which is visible in the table: estradiol carries a phenol group and testosterone a ketone, and estradiol has lost a carbon at 272.4 against 288.4. Everyone makes both. Testosterone predominates in men and drives muscle, bone density and body hair; estradiol predominates in women and drives the menstrual cycle, and it is also essential to bone health in men, through exactly that aromatase conversion. Both are steroids built from cholesterol, four fused rings apiece.
Sources and notes
- The paragraphfrom sourceMoleculeFinder comparison notes
Questions
- What is the difference between Estradiol and Testosterone?
- Estradiol is made from testosterone by the enzyme aromatase; testosterone predominates in men and estradiol in women, and everyone makes both.
- Is Estradiol bigger than Testosterone?
- Testosterone is the heavier molecule, 288.4 g/mol against 272.4 g/mol for Estradiol. Estradiol is C18H24O2 and Testosterone is C19H28O2.
Sources and notes
- The answersfrom sourceMoleculeFinderThe first is the pair's answer line; the others are read off the table above.