SHEET /vs/diltiazem-vs-verapamil · COMPARISON
Diltiazem vs Verapamil: what is the difference?
How they differ
from source
Diltiazem and verapamil are the two calcium channel blockers that act on the heart itself as well as on blood vessels, which sets them apart from amlodipine and the other dihydropyridines. That is why both are used to slow some fast heart rhythms, not only for blood pressure and angina. They come from different chemical families: diltiazem is a benzothiazepine with a sulfur in its ring, C22H26N2O4S at 414.5, while verapamil is a phenylalkylamine, C27H38N2O4 at 454.6. Verapamil has the stronger effect on the heart's rhythm, and diltiazem sits between it and the dihydropyridines. Both are prescription medicines, sold as Cardizem and as Calan.
Side by side
| Diltiazem | Verapamil | |
|---|---|---|
| Formula | C22H26N2O4S | C27H38N2O4 |
| Molecular weight | 414.5 g/mol | 454.6 g/mol |
| Family | Blood-pressure medicines | Blood-pressure medicines |
| Everyday group | Prescription medicine | Prescription medicine |
| Functional groups | Aromatics, Esters, Amides, Ethers | Aromatics, Ethers |
| GHS signal wordThe supplier-filed hazard label, not a statement about ordinary use. | not recorded | Danger |
| Oral LD50A single acute animal measure. It ranks nothing about human safety. | not recorded | 114 mg/kg (oral, rat) |
| CAS number | 42399-41-7 | 52-53-9 |
| PubChem CID | 39186 | 2520 |
Common questions
- What is the difference between Diltiazem and Verapamil?
- Diltiazem and verapamil are the two calcium channel blockers that act on the heart itself as well as on blood vessels, which sets them apart from amlodipine and the other dihydropyridines. That is why both are used to slow some fast heart rhythms, not only for blood pressure and angina. They come from different chemical families: diltiazem is a benzothiazepine with a sulfur in its ring, C22H26N2O4S at 414.5, while verapamil is a phenylalkylamine, C27H38N2O4 at 454.6.
- Is Diltiazem bigger than Verapamil?
- Verapamil is the heavier molecule, 454.6 g/mol against 414.5 g/mol for Diltiazem. Diltiazem is C22H26N2O4S and Verapamil is C27H38N2O4.