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β-Carotene vs Retinol: what is the difference?

Retinol is preformed vitamin A that the body uses directly, while beta-carotene is two retinol units joined, cut into vitamin A only as the body needs it.

β-CaroteneC40H56
RetinolC20H30O
Sources and notes
  • The sentence under the titlefrom sourceMoleculeFinder comparison notesThe pair's answer line.
  • The two drawingscomputedMoleculeFinder rule (RDKit MCS)Drawn the same way round on the skeleton they share. Aligned; 21 atoms differ, too many to mark as one group.
  • Structural similaritycomputedRDKit Morgan/Tanimoto0.80 of 1, a Morgan fingerprint Tanimoto coefficient. It measures shape, not effect.

Side by side

 β-CaroteneRetinol
Molecular weightCalculated PubChem536.9 g/molC40H56286.5 g/molC20H30O
Hydrogen-bond donorsCalculated PubChem01
Where each turns upEditorial MoleculeFinder food and product lists
FamilyEditorial MoleculeFinder curatedCarotenoidsVitamins
Everyday groupEditorial MoleculeFinder curatedPlantNutrient
Chemical groupsCalculated Found by rule (RDKit)Not recordedAlcohols
Hazard labelReported ECHA via PubChemNot recordedDanger
The supplier-filed hazard label's signal word, not a statement about ordinary use.
Oral LD50Measured HSDB via PubChemNot recorded2,570 mg/kgpure retinol, mouse, oral
A single acute animal measure. It ranks nothing about human safety.
Sources and notes
  • Molecular weightcomputedPubChemComputed from the structure; the formula is under each weight.
  • Hydrogen-bond donorscomputedPubChemThe hydrogens on nitrogen or oxygen that each molecule can lend to a hydrogen bond, counted from its structure.
  • Where each turns upfrom sourceMoleculeFinder food and product listsEach amount is an editorial figure from our lists, not a measurement of any one product. Each mark is set by hand on the list, never inferred.
  • Familyfrom sourceMoleculeFinder curated
  • Everyday groupfrom sourceMoleculeFinder curated
  • Chemical groupscomputedFound by rule (RDKit)Each group is found in the structure by a chemical pattern.
  • Hazard labelfrom sourceECHA via PubChem
  • Oral LD50from sourceHSDB via PubChem
  • ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
  • Identifiersfrom sourcePubChemPubChem CID 5280489 (β-Carotene) and 445354 (Retinol).

In more detail

The body makes that cut in the gut wall. That conversion is the entire difference. Retinol is preformed vitamin A from animal sources and is used directly, so it accumulates and can reach toxic levels; beta-carotene is converted only as needed, so surplus is stored in fat and skin rather than causing vitamin A toxicity. Eating a very large amount of beta-carotene turns skin orange, which is harmless and reversible. Beta-carotene is the orange of carrots and sweet potato and is nearly twice retinol's weight at 536.9 against 286.5. Conversion efficiency varies a great deal between people.

Sources and notes
  • The paragraphfrom sourceMoleculeFinder comparison notes

Questions

What is the difference between β-Carotene and Retinol?
Retinol is preformed vitamin A that the body uses directly, while beta-carotene is two retinol units joined, cut into vitamin A only as the body needs it.
Is β-Carotene bigger than Retinol?
β-Carotene is the heavier molecule, 536.9 g/mol against 286.5 g/mol for Retinol. β-Carotene is C40H56 and Retinol is C20H30O.
Sources and notes
  • The answersfrom sourceMoleculeFinderThe first is the pair's answer line; the others are read off the table above.

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