Aripiprazole vs Risperidone: what is the difference?
Risperidone blocks the dopamine D2 receptor outright, while aripiprazole is a partial agonist that switches it on slightly, so it raises prolactin less.
Sources and notes
- The sentence under the titlefrom sourceMoleculeFinder comparison notesThe pair's answer line.
- The two drawingscomputedMoleculeFinder rule (RDKit MCS)Each molecule's own drawing, as its page shows it. The common core, 6 of 30 atoms, is too small to align on.
Side by side
| Aripiprazole | Risperidone | |
|---|---|---|
| Molecular weightCalculated PubChem | 448.4 g/molC23H27Cl2N3O2 | 410.5 g/molC23H27FN4O2 |
| Hydrogen-bond donorsCalculated PubChem | 1 | 0 |
| FamilyEditorial MoleculeFinder curated | Antipsychotics | Antipsychotics |
| Everyday groupEditorial MoleculeFinder curated | Prescription medicine | Prescription medicine |
| Chemical groupsCalculated Found by rule (RDKit) | Aromatics, Amides, Ethers, Halogenated | Aromatics, Halogenated |
| Hazard labelReported ECHA, HSDB via PubChem; ECHA via PubChem | Danger | Danger |
| The supplier-filed hazard label's signal word, not a statement about ordinary use. | ||
Sources and notes
- Molecular weightcomputedPubChemComputed from the structure; the formula is under each weight.
- Hydrogen-bond donorscomputedPubChemThe hydrogens on nitrogen or oxygen that each molecule can lend to a hydrogen bond, counted from its structure.
- Familyfrom sourceMoleculeFinder curated
- Everyday groupfrom sourceMoleculeFinder curated
- Chemical groupscomputedFound by rule (RDKit)Each group is found in the structure by a chemical pattern.
- Hazard labelfrom sourceECHA, HSDB via PubChem; ECHA via PubChem
- ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
- Identifiersfrom sourcePubChemPubChem CID 60795 (Aripiprazole) and 5073 (Risperidone).
In more detail
Both are atypical antipsychotics and they treat the dopamine receptor in opposite ways. Risperidone is a straightforward D2 blocker with strong 5-HT2A blocking added, so at higher amounts it behaves much like an older antipsychotic, including a marked rise in prolactin. Aripiprazole is a partial agonist: it occupies the same receptor and produces a low level of activation, damping signalling where dopamine is high and supporting it where dopamine is low. That mechanism is why aripiprazole tends to be more activating and less prolactin raising, while risperidone is the more sedating. Aripiprazole is the heavier of the two at 448.4 against 410.5.
Sources and notes
- The paragraphfrom sourceMoleculeFinder comparison notes
Questions
- What is the difference between Aripiprazole and Risperidone?
- Risperidone blocks the dopamine D2 receptor outright, while aripiprazole is a partial agonist that switches it on slightly, so it raises prolactin less.
- Is Aripiprazole bigger than Risperidone?
- Aripiprazole is the heavier molecule, 448.4 g/mol against 410.5 g/mol for Risperidone. Aripiprazole is C23H27Cl2N3O2 and Risperidone is C23H27FN4O2.
Sources and notes
- The answersfrom sourceMoleculeFinderThe first is the pair's answer line; the others are read off the table above.