moleculefinder

Valaciclovir

C13H20N6O4324.34 g/mol Calculated

Also called L-valyl Ester Acyclovir, L-valylacyclovir, Val-ACV and ValACV.

An antiviral sold as Valtrex for herpes and shingles. It is aciclovir with a valine attached so the gut absorbs it better.

Sources and notes
  • The introductionfrom sourceMoleculeFinder curated
  • Other namesfrom sourcePubChem / Wikidata
  • Formula and weightcomputedPubChem
  • 2D drawingcomputedPubChem structure, drawn by RDKit
  • 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.

Where you encounter it

Dispensed on prescription, not sold on a shelf.

Sources and notes
  • The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.

Explore its structure

Choose a part to light it up.

A C=O joined through an oxygen to another carbon, the link an acid and an alcohol make when they combine. Water can split it back into the two.

From: standard chemistry.

Sources and notes
  • The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
  • The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.

Compare a related molecule

Aciclovir

Valaciclovir

Valaciclovir is aciclovir with the amino acid valine attached, which the body removes, so swallowed valaciclovir delivers far more aciclovir to the blood.

Aciclovir vs Valaciclovir, side by side
Sources and notes
  • The sentencefrom sourceMoleculeFinder comparison notesThe pair's answer line.
  • The two drawingscomputedPubChem structures, drawn by RDKitThe two drawings side by side.

Properties and sources

Calculated by PubChem

Molecular formula
C13H20N6O4
Molecular weight
324.34 g/mol
XLogP3octanol/water, log units
−0.9
Polar surface areatopological
147 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
8
Complexity
483

Reported Hazard label (GHS), ECHA via PubChem

Warning Irritant pictogram (GHS07); hazard statements H302

Reported Licence

The US Food and Drug Administration licenses Valaciclovir for human use (NDA 020487, authorized June 23, 1995). Drugs@FDA

Groups it belongs to

Category
Prescription medicine
Family
Antivirals
Chemical groups
Amines, Esters, Ethers
Elements
Nitrogen
Hazard classes
Irritant, GHS Warning
SMILESCC(C)[C@@H](C(=O)OCCOCN1C=NC2=C1N=C(NC2=O)N)N

PubChem CID 135398742 · Wikidata Q418594 · InChIKey HDOVUKNUBWVHOX-QMMMGPOBSA-N · Data refreshed

How MoleculeFinder sources and labels its data

Questions
What is Valaciclovir?
An antiviral sold as Valtrex for herpes and shingles. It is aciclovir with a valine attached so the gut absorbs it better.
How toxic is Valaciclovir?
Its GHS hazard label carries the signal word Warning and the hazard pictogram Irritant. from source
What kind of molecule is Valaciclovir?
Valaciclovir has the formula C13H20N6O4 and a molecular weight of 324.34 g/mol. MoleculeFinder files it under antivirals, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
Who licenses Valaciclovir as a medicine?
The US Food and Drug Administration licenses Valaciclovir for human use (NDA 020487, authorized June 23, 1995). from source
Sources and notes
  • Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
  • Hazard labelfrom sourceECHA via PubChemThe label combines these classifications.
  • ECHAfrom sourceAttributionSource: European Chemicals Agency, echa.europa.eu.
  • Licencefrom sourceDrugs@FDARead 2026-10-21.
  • Data refreshedfrom sourceMoleculeFinder2026-11-09

Keep exploring

Compared side by side with valaciclovirAciclovirC8H11N5O3
Sources and notes
  • Compared side by sidefrom sourceMoleculeFinder comparison notesA molecule we compare it with on its own page.
  • The drawingscomputedPubChem structures, drawn by RDKit