Suzetrigine
A non-opioid painkiller approved in 2025 that blocks Nav1.8, a sodium channel found mainly in pain-sensing nerves; the FDA called it the first new class of pain medicine in over 20 years.
Sources and notes
- The introductionfrom sourceMoleculeFinder curated
- Formula and weightcomputedPubChem
- 2D drawingcomputedPubChem structure, drawn by RDKit
- 3D modelfrom sourcePubChem 3D conformerLoaded after the page has painted, and on a phone only when you ask for it; the 2D drawing shows until it arrives.
Where you encounter it
Dispensed on prescription, not sold on a shelf. Suzetrigine on the product labels we hold.
Medicines
Every product and list we hold
Sources and notes
- The product labels and their strengthsfrom sourceDailyMed (FDA label)Each label lists the molecule as an ingredient, and an active ingredient at the strength shown.
- How it gets therefrom sourceMoleculeFinder curatedEach mark is set by hand on our lists, never inferred; a label's ingredient is added by the maker. A row with no mark data says Not marked.
- The line abovefrom sourceMoleculeFinder curatedFrom the group the molecule belongs to.
Explore its structure
Choose a part to light it up.
A C=O bonded to a nitrogen, the same link that joins amino acids in a protein. It is sturdy, and its nitrogen is not a base the way an amine's is.
From: standard chemistry.
An oxygen bridging two carbons, written C-O-C. It accepts hydrogen bonds but has no hydrogen to give, and it is slow to react.
From: standard chemistry.
Fluorine, chlorine, bromine or iodine bonded to carbon. Each pulls electrons toward itself, and each is larger than the hydrogen the carbon would otherwise carry.
From: standard chemistry.
Sources and notes
- The drawingcomputedPubChem structure, drawn by RDKitThe page's one shipped drawing, with the chosen part lit in amber under it.
- The partscomputedFound by ruleEach part is found by a chemical pattern, never picked by hand atom by atom; its words say where they come from.
Properties and sources
Calculated by PubChem
- Molecular formula
- C21H20F5N3O4
- Molecular weight
- 473.4 g/mol
- XLogP3octanol/water, log units
- 3
- Polar surface areatopological
- 104 Ų
- H-bond donors
- 2
- H-bond acceptors
- 10
- Rotatable bonds
- 5
- Complexity
- 741
Reported Licence
The US Food and Drug Administration licenses Suzetrigine for human use (NDA 219209, authorized January 30, 2025), as Journavx. Drugs@FDA
Groups it belongs to
- Category
- Prescription medicine
- Family
- Non-opioid painkillers
- Chemical groups
- Aromatics, Amides, Ethers, Halogenated
C[C@H]1[C@H]([C@@H](O[C@@]1(C)C(F)(F)F)C(=O)NC2=…86 charactersPubChem CID 156445116 · Wikidata Q123481189 · InChIKey XSQUJFKRXZMOKA-PAFIKIDNSA-N · Data refreshed
Questions
- What is Suzetrigine?
- A non-opioid painkiller approved in 2025 that blocks Nav1.8, a sodium channel found mainly in pain-sensing nerves; the FDA called it the first new class of pain medicine in over 20 years.
- What kind of molecule is Suzetrigine?
- Suzetrigine has the formula C21H20F5N3O4 and a molecular weight of 473.4 g/mol. MoleculeFinder files it under non-opioid painkillers, in the prescription medicine group. from sourcefrom sourcefrom sourcefrom source
- Who licenses Suzetrigine as a medicine?
- The US Food and Drug Administration licenses Suzetrigine for human use (NDA 219209, authorized January 30, 2025), as Journavx. from source
Sources and notes
- Calculated valuescomputedPubChemComputed from the structure, so no laboratory conditions apply; complexity is PubChem's own structural score.
- Licencefrom sourceDrugs@FDARead 2026-10-21.
- Data refreshedfrom sourceMoleculeFinder2026-11-09